Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo.

  • Authors:
    • S W Melchior
    • L G Brown
    • W D Figg
    • J E Quinn
    • R A Santucci
    • J Brunner
    • J W Thüroff
    • P H Lange
    • R L Vessella
  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/ijo.14.3.501
  • Pages: 501-509
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Abstract

Phenylbutyrate (PB) is a potent differentiating agent and currently under investigation for the treatment of prostate cancer (CaP) and other malignancies. We have studied the impact of PB in vitro and in vivo on differentiation, proliferation and apoptosis in the LNCaP and LuCaP 23.1 prostate cancer xenograft models. In vitro we found that i) PB increased PSA secretion/cell, ii) inhibited cell proliferation in a time- and dose-dependent manner resulting in a cell cycle arrest in G1-phase and iii) induced apoptosis at concentrations of 2.5 mM after 3 days of treatment. In PB treated animals tumor growth stabilized or regressed. Combination of castration and PB treatment had a synergistic antiproliferative effect. The growth-inhibitory and differentiating properties and a low toxicity profile of PB provide rationale for further clinical studies in patients with CaP.

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Mar 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Melchior S, Brown L, Figg W, Quinn J, Santucci R, Brunner J, Thüroff J, Lange P and Vessella R: Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo.. Int J Oncol 14: 501-509, 1999
APA
Melchior, S., Brown, L., Figg, W., Quinn, J., Santucci, R., Brunner, J. ... Vessella, R. (1999). Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo.. International Journal of Oncology, 14, 501-509. https://doi.org/10.3892/ijo.14.3.501
MLA
Melchior, S., Brown, L., Figg, W., Quinn, J., Santucci, R., Brunner, J., Thüroff, J., Lange, P., Vessella, R."Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo.". International Journal of Oncology 14.3 (1999): 501-509.
Chicago
Melchior, S., Brown, L., Figg, W., Quinn, J., Santucci, R., Brunner, J., Thüroff, J., Lange, P., Vessella, R."Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo.". International Journal of Oncology 14, no. 3 (1999): 501-509. https://doi.org/10.3892/ijo.14.3.501