Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.

  • Authors:
    • M Zhang
    • Y Endo
    • T Sasaki
  • View Affiliations

  • Published online on: Monday, March 1, 1999
  • Pages:543-552 DOI: 10.3892/ijo.14.3.543
0

Abstract

2'-C-Cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) is a novel 2'-deoxycytidine (dCyd) analogue with potent antitumor activity. To elucidate the determinants of chemosensitivity to CNDAC, the intracellular accumulation of CNDAC and the activities of dCyd kinase and cytidine deaminase were investigated in transformed NIH 3T3 cells with different genetic bases. The results indicate that the primary determinants of chemosensitivity to CNDAC are different in each cell type, but membrane transportation and the enzyme activities of dCyd kinase and cytidine deaminase are critical factors underlying the antitumor action of CNDAC. Moreover, the expression or function of these factors appears to be influenced by the activation of various oncogenes.

Related Articles

Journal Cover

March 1999
Volume 14 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

2015 Impact Factor: 3.018
Ranked #30/211 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Zhang, M., Endo, Y., & Sasaki, T. (1999). Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.. International Journal of Oncology, 14, 543-552. http://dx.doi.org/10.3892/ijo.14.3.543
MLA
Zhang, M., Endo, Y., Sasaki, T."Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.". International Journal of Oncology 14.3 (1999): 543-552.
Chicago
Zhang, M., Endo, Y., Sasaki, T."Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.". International Journal of Oncology 14, no. 3 (1999): 543-552. http://dx.doi.org/10.3892/ijo.14.3.543