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Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.

  • Authors:
    • F Franek
    • A Holy
    • I Votruba
    • T Eckschlager

  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijo.14.4.745
  • Pages: 745-797
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Abstract

Acyclic nucleotide analogues perturb DNA replication by terminating the growing DNA chain. The analogues selected for testing on human leukemia cell lines, namely 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP), and 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) exhibited growth-inhibiting activity at low concentrations, and apoptosis-inducing activity at high concentrations. A common feature was a reduction of the proportion of G1 cell cycle phase. Activities of the analogues increased in the order PMEA

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Journal Cover

Apr 1999
Volume 14 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Franek F, Holy A, Votruba I and Eckschlager T: Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.. Int J Oncol 14: 745-797, 1999
APA
Franek, F., Holy, A., Votruba, I., & Eckschlager, T. (1999). Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.. International Journal of Oncology, 14, 745-797. https://doi.org/10.3892/ijo.14.4.745
MLA
Franek, F., Holy, A., Votruba, I., Eckschlager, T."Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.". International Journal of Oncology 14.4 (1999): 745-797.
Chicago
Franek, F., Holy, A., Votruba, I., Eckschlager, T."Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.". International Journal of Oncology 14, no. 4 (1999): 745-797. https://doi.org/10.3892/ijo.14.4.745