Modulation of integrin expression on mesotheliomas: the role of different histotypes in invasiveness.

  • Authors:
    • A Giuffrida
    • G Vianale
    • M Di Muzio
    • H I Pass
    • A Coletti
    • P Birarelli
    • A Procopio
    • A Modesti
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijo.15.3.437
  • Pages: 437-479
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Abstract

The in vitro and in vivo integrin expression in human pleural malignant mesothelioma (MM) of three different histotypes was studied. Cell lines from MM of epithelioid (E1), fibrous (F1), byphasic histotype (B1) and normal mesothelial cells (NM) were analysed for the surface expression of alpha2, alpha3, alpha4, alpha5, alpha6, alphav, beta1, beta3, beta4 subunits and alphavbeta5 integrins. We found that alpha6, beta4 subunits and alphavbeta5, weakly detectable on NM cells, were expressed on MM cells. The beta3 subunit, well expressed on NM cells, was absent on MM cells. Differential expression among histotypes was observed, the MM-E1 was the least and the MM-B1 the most positive. Specimens for each MM histotype, were analysed by immunohistochemistry. The alpha6 and alphav subunits were more evident on the epithelioid histotype. Intense staining for beta3 and beta4 subunits, was found in all MM, particularly in invading cells, while the alpha5, and alphavbeta5 integrins were variously expressed. The different histotypes can affect the in vitro integrin expression and may indicate a preferential involvement of some subunits in vivo during MM tumor progression.

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Sep 1999
Volume 15 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Giuffrida A, Vianale G, Di Muzio M, Pass H, Coletti A, Birarelli P, Procopio A and Modesti A: Modulation of integrin expression on mesotheliomas: the role of different histotypes in invasiveness.. Int J Oncol 15: 437-479, 1999
APA
Giuffrida, A., Vianale, G., Di Muzio, M., Pass, H., Coletti, A., Birarelli, P. ... Modesti, A. (1999). Modulation of integrin expression on mesotheliomas: the role of different histotypes in invasiveness.. International Journal of Oncology, 15, 437-479. https://doi.org/10.3892/ijo.15.3.437
MLA
Giuffrida, A., Vianale, G., Di Muzio, M., Pass, H., Coletti, A., Birarelli, P., Procopio, A., Modesti, A."Modulation of integrin expression on mesotheliomas: the role of different histotypes in invasiveness.". International Journal of Oncology 15.3 (1999): 437-479.
Chicago
Giuffrida, A., Vianale, G., Di Muzio, M., Pass, H., Coletti, A., Birarelli, P., Procopio, A., Modesti, A."Modulation of integrin expression on mesotheliomas: the role of different histotypes in invasiveness.". International Journal of Oncology 15, no. 3 (1999): 437-479. https://doi.org/10.3892/ijo.15.3.437