Mutation analysis of the Smad3 gene in human ovarian cancers.

  • Authors:
    • D Wang
    • T Kanuma
    • F Takama
    • H Mizumuma
    • Y Ibuki
    • N Wake
    • A Mogi
    • Y Shitara
    • K Hagiwara
    • S Takenoshita
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.949
  • Pages: 949-1002
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Abstract

The Smad3 gene is a member of the Smad family, vertebrate homologues of Drosophila Mad, and its gene product is a cytoplasmic element in the transforming growth factor-beta (TGF-beta) signaling pathway. Mutations in TGF-beta receptors and their cytoplasmic elements of transduction signals commonly accompany various cancers. Using PCR-SSCP analysis we searched for the presence of Smad3 gene mutations in 36 human ovarian cancers, and found that 15 cases (41. 7%) had a polymorphism at codon 103. Because this mutation was not accompanied by amino acid replacement, the present results show that the mutations in the Smad3 gene are unlikely to be involved in human ovarian cancers.

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Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang D, Kanuma T, Takama F, Mizumuma H, Ibuki Y, Wake N, Mogi A, Shitara Y, Hagiwara K, Takenoshita S, Takenoshita S, et al: Mutation analysis of the Smad3 gene in human ovarian cancers.. Int J Oncol 15: 949-1002, 1999
APA
Wang, D., Kanuma, T., Takama, F., Mizumuma, H., Ibuki, Y., Wake, N. ... Takenoshita, S. (1999). Mutation analysis of the Smad3 gene in human ovarian cancers.. International Journal of Oncology, 15, 949-1002. https://doi.org/10.3892/ijo.15.5.949
MLA
Wang, D., Kanuma, T., Takama, F., Mizumuma, H., Ibuki, Y., Wake, N., Mogi, A., Shitara, Y., Hagiwara, K., Takenoshita, S."Mutation analysis of the Smad3 gene in human ovarian cancers.". International Journal of Oncology 15.5 (1999): 949-1002.
Chicago
Wang, D., Kanuma, T., Takama, F., Mizumuma, H., Ibuki, Y., Wake, N., Mogi, A., Shitara, Y., Hagiwara, K., Takenoshita, S."Mutation analysis of the Smad3 gene in human ovarian cancers.". International Journal of Oncology 15, no. 5 (1999): 949-1002. https://doi.org/10.3892/ijo.15.5.949