Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein.
- M Fujimoto
- K I Matsumoto
- S M Iguchi-Ariga
- H Ariga
Affiliations: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
- Published online on: February 1, 2000 https://doi.org/10.3892/ijo.16.2.245
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Two cDNAs encoding mouse MSSP and Scr3 were cloned. Both proteins, like those in humans, share significant homology of the region near the N-terminus containing the RNA-binding protein, RNP, while little homology exists near the C-terminal region of the proteins. Expression of mouse MSSP and Scr3 in mouse tissues were examined by Northern blot hybridization and both mRNAs were ubiquitously expressed in all the tissues except for testis, where the smaller sizes of MSSP mRNAs, but not Scr3 mRNA, were highly expressed. Then, the genomic DNA of mouse MSSP was cloned. Mouse genomic MSSP gene was comprised of at least 13 exons over the region spanning 60 kb. Furthermore, a chromosome location of human MSSP gene was identified at 2q24 by FISH mapping.