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Diverse regulations of albumin gene expression by hepatocyte growth factor in HepG2 human hepatoma cells and primary culture of rat hepatocytes.

  • Authors:
    • K Iseki
    • K Nakao
    • K Nakata
    • Y Shima
    • K Hamasaki
    • Y Kato
    • N Ishii
    • K Eguchi

  • View Affiliations

  • Published online on: June 1, 2000     https://doi.org/10.3892/ijo.16.6.1141
  • Pages: 1141-1146
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The effects of HGF on albumin gene expression in HepG2 human hepatoma cells and rat hepatocytes were investigated. HGF reduced the levels of albumin mRNA in HepG2 cells but the level was augmented in rat hepatocytes. By the transfection assay, HGF stimulated albumin promoter activity but repressed alpha-fetoprotein (AFP) enhancer activity regulating both AFP and albumin promoters in HepG2 cells. In contrast, HGF stimulated albumin promoter and AFP enhancer activities in rat hepatocytes. These results suggest that HGF elicits diverse responses of albumin gene expression in HepG2 cells and rat hepatocytes through the different biological actions on AFP enhancer in these cells.

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Jun 2000
Volume 16 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Iseki K, Nakao K, Nakata K, Shima Y, Hamasaki K, Kato Y, Ishii N and Eguchi K: Diverse regulations of albumin gene expression by hepatocyte growth factor in HepG2 human hepatoma cells and primary culture of rat hepatocytes.. Int J Oncol 16: 1141-1146, 2000
APA
Iseki, K., Nakao, K., Nakata, K., Shima, Y., Hamasaki, K., Kato, Y. ... Eguchi, K. (2000). Diverse regulations of albumin gene expression by hepatocyte growth factor in HepG2 human hepatoma cells and primary culture of rat hepatocytes.. International Journal of Oncology, 16, 1141-1146. https://doi.org/10.3892/ijo.16.6.1141
MLA
Iseki, K., Nakao, K., Nakata, K., Shima, Y., Hamasaki, K., Kato, Y., Ishii, N., Eguchi, K."Diverse regulations of albumin gene expression by hepatocyte growth factor in HepG2 human hepatoma cells and primary culture of rat hepatocytes.". International Journal of Oncology 16.6 (2000): 1141-1146.
Chicago
Iseki, K., Nakao, K., Nakata, K., Shima, Y., Hamasaki, K., Kato, Y., Ishii, N., Eguchi, K."Diverse regulations of albumin gene expression by hepatocyte growth factor in HepG2 human hepatoma cells and primary culture of rat hepatocytes.". International Journal of Oncology 16, no. 6 (2000): 1141-1146. https://doi.org/10.3892/ijo.16.6.1141