Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.

  • Authors:
    • C Page
    • M Huang
    • X Jin
    • K Cho
    • J Lilja
    • R K Reynolds
    • J Lin
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijo.17.1.23
  • Pages: 23-31
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Abstract

We examined whether the persistent activation of AKT or Stat3 oncogene product is present in prostate, breast, and cervical cancer cells. We found that some prostate and breast cancer cell lines express high levels of phosphorylated AKT. Interestingly, the cancer cells, which only express low levels of phosphorylated AKT express high levels of phosphorylated Stat3. AKT or Stat3 is also highly phosphorylated in human papilloma virus-negative cervical cancer cells. Therefore, these results indicate that AKT and Stat3 are highly phosphorylated in some breast, prostate and cervical cancer cells, which may play a role in tumorigenesis of these cancers.

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July 2000
Volume 17 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Page, C., Huang, M., Jin, X., Cho, K., Lilja, J., Reynolds, R., & Lin, J. (2000). Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.. International Journal of Oncology, 17, 23-31. https://doi.org/10.3892/ijo.17.1.23
MLA
Page, C., Huang, M., Jin, X., Cho, K., Lilja, J., Reynolds, R., Lin, J."Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.". International Journal of Oncology 17.1 (2000): 23-31.
Chicago
Page, C., Huang, M., Jin, X., Cho, K., Lilja, J., Reynolds, R., Lin, J."Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.". International Journal of Oncology 17, no. 1 (2000): 23-31. https://doi.org/10.3892/ijo.17.1.23