Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.

  • Authors:
    • A Rácz
    • N Brass
    • M Höfer
    • G W Sybrecht
    • K Remberger
    • E U Meese
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijo.17.1.67
  • Pages: 67-140
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Abstract

Gene amplification is a frequent event in lung cancer, specifically in squamous cell lung carcinoma. Recently, we reported amplifications on chromosomal bands 3q26.1-q26.3 with the genes BCHE and SLC2A2 amplified in 40% of squamous cell lung carcinomas. Here, we identified an amplified domain within chromosomal bands 1pter-p33 in squamous cell lung carcinoma using reverse chromosome painting. A panel of nine genes which have previously been assigned to region 1pter-p33 was tested for amplification using comparative PCR. The ENO1 gene that encodes enolase and the PAX7 gene that encodes a transcription factor were most frequently amplified. Specifically, the gene ENO1 was amplified in six and the gene PAX7 in five out of 37 cases which included both biopsies and paraffin-embedded tissues of squamous cell lung carcinomas. In total, we identified amplifications of at least one gene at bands 1pter-p33 in 10 out of 37 tumors (27%). Together, our data indicate that a novel and frequent amplification unit is present in squamous cell lung carcinoma with the center of the amplified domain in the vicinity of the genes PAX7 and ENO1.

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Jul 2000
Volume 17 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Rácz A, Brass N, Höfer M, Sybrecht G, Remberger K and Meese E: Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.. Int J Oncol 17: 67-140, 2000
APA
Rácz, A., Brass, N., Höfer, M., Sybrecht, G., Remberger, K., & Meese, E. (2000). Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.. International Journal of Oncology, 17, 67-140. https://doi.org/10.3892/ijo.17.1.67
MLA
Rácz, A., Brass, N., Höfer, M., Sybrecht, G., Remberger, K., Meese, E."Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.". International Journal of Oncology 17.1 (2000): 67-140.
Chicago
Rácz, A., Brass, N., Höfer, M., Sybrecht, G., Remberger, K., Meese, E."Gene amplification at chromosome 1pter-p33 including the genes PAX7 and ENO1 in squamous cell lung carcinoma.". International Journal of Oncology 17, no. 1 (2000): 67-140. https://doi.org/10.3892/ijo.17.1.67