Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.

  • Authors:
    • E M Flores-Stadler
    • P M Chou
    • N Barquin
    • M Thangavelu
    • F Gonzalez-Crussi
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  • Published online on: September 1, 2000     https://doi.org/10.3892/ijo.17.3.433
  • Pages: 433-440
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Abstract

We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromosomes 8, 11 and 17. Trisomy 8 and 11 were detected in a high percentage of nuclei in cases of congenital/infantile fibrosarcomas (ranging from 45 to 80%), and in a low grade fibrosarcoma in an older child (23%). Only gains of chromosome 17 were detected in a case of infantile fibromatosis (22%). In this study we have found that given the unconventional histopathologic features, the detection of more than one non-random chromosomal gains by FISH, may aid in further defining fibrous tumors in children, and may be useful as an ancillary diagnostic test in the future.

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Sep 2000
Volume 17 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Flores-Stadler E, Chou P, Barquin N, Thangavelu M and Gonzalez-Crussi F: Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.. Int J Oncol 17: 433-440, 2000
APA
Flores-Stadler, E., Chou, P., Barquin, N., Thangavelu, M., & Gonzalez-Crussi, F. (2000). Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.. International Journal of Oncology, 17, 433-440. https://doi.org/10.3892/ijo.17.3.433
MLA
Flores-Stadler, E., Chou, P., Barquin, N., Thangavelu, M., Gonzalez-Crussi, F."Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.". International Journal of Oncology 17.3 (2000): 433-440.
Chicago
Flores-Stadler, E., Chou, P., Barquin, N., Thangavelu, M., Gonzalez-Crussi, F."Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.". International Journal of Oncology 17, no. 3 (2000): 433-440. https://doi.org/10.3892/ijo.17.3.433