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Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.

  • Authors:
    • A Sjöström
    • P Bue
    • P Malmstrom
    • J Carlsson

  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/ijo.17.3.559
  • Pages: 559-623
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Abstract

The binding of a targeting agent, 125I-EGF-dextran, to epidermal growth factor (EGF) receptors in tumour spheroids of a human bladder cancer cell line was studied. The accumulation of radioactivity was continuous up to at least 48 h in the peripheral cells of the spheroids, which in comparison with the binding pattern of 125I-EGF indicated that the cells had a limited capacity to degrade the EGF-dextran. The 125I-EGF-dextran was of two different sizes, 28 and 76 kDa, but this did not affect the binding patterns and the results were very similar. The EGF-dextran conjugates had qualities that are of interest for tumour targeting.

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Sep 2000
Volume 17 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Sjöström A, Bue P, Malmstrom P and Carlsson J: Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.. Int J Oncol 17: 559-623, 2000
APA
Sjöström, A., Bue, P., Malmstrom, P., & Carlsson, J. (2000). Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.. International Journal of Oncology, 17, 559-623. https://doi.org/10.3892/ijo.17.3.559
MLA
Sjöström, A., Bue, P., Malmstrom, P., Carlsson, J."Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.". International Journal of Oncology 17.3 (2000): 559-623.
Chicago
Sjöström, A., Bue, P., Malmstrom, P., Carlsson, J."Binding of 125I after administration of 125I-EGF-dextran, 125I-EGF or 125I to human bladder cancer spheroids.". International Journal of Oncology 17, no. 3 (2000): 559-623. https://doi.org/10.3892/ijo.17.3.559