Galectin-1 gene expression and methylation state in human T leukemia cell lines.

  • Authors:
    • P Salvatore
    • G Benvenuto
    • R Pero
    • F Lembo
    • C B Bruni
    • L Chiariotti
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/ijo.17.5.1015
  • Pages: 1015-1023
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Abstract

Galectin-1 has been demonstrated to be a mediator of T-cell apoptosis acting on activated T-cells and, in a selective manner, on different T leukemia cell lines. Here we show that the sensitivity to galectin-1 is associated with repression of the endogenous galectin-1 gene whereas non-sensitive cells express high levels of galectin-1. Repression of galectin-1 gene in sensitive cells is associated with hyper-methylation of the promoter region. Transient treatment of non-expressing cells with the demethylating agent 5-azacytidine led to irreversible demethylation and subsequent reactivation of galectin-1 gene.

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Nov 2000
Volume 17 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Salvatore P, Benvenuto G, Pero R, Lembo F, Bruni C and Chiariotti L: Galectin-1 gene expression and methylation state in human T leukemia cell lines.. Int J Oncol 17: 1015-1023, 2000
APA
Salvatore, P., Benvenuto, G., Pero, R., Lembo, F., Bruni, C., & Chiariotti, L. (2000). Galectin-1 gene expression and methylation state in human T leukemia cell lines.. International Journal of Oncology, 17, 1015-1023. https://doi.org/10.3892/ijo.17.5.1015
MLA
Salvatore, P., Benvenuto, G., Pero, R., Lembo, F., Bruni, C., Chiariotti, L."Galectin-1 gene expression and methylation state in human T leukemia cell lines.". International Journal of Oncology 17.5 (2000): 1015-1023.
Chicago
Salvatore, P., Benvenuto, G., Pero, R., Lembo, F., Bruni, C., Chiariotti, L."Galectin-1 gene expression and methylation state in human T leukemia cell lines.". International Journal of Oncology 17, no. 5 (2000): 1015-1023. https://doi.org/10.3892/ijo.17.5.1015