Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).

  • Authors:
    • J Weisberger
    • C D Wu
    • Z Liu
    • J Y Wong
    • M R Melamed
    • Z Darzynkiewicz
    • W Gorczyca
  • View Affiliations

  • Published online on: December 1, 2000     https://doi.org/10.3892/ijo.17.6.1165
  • Pages: 1165-1242
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Abstract

The introduction of monoclonal antibodies (mAbs) for cell immunophenotyping and use of flow cytometry with the progressively improving software for multivariate analyses have revolutionized the diagnosis and influenced the classification of hematologic neoplasms. In this review we focus on the practical application of flow cytometry in the diagnosis and classification of malignant lymphomas and related lymphoproliferative disorders with special emphasis on differential diagnosis. A general approach to the utilization of flow cytometry (FC) in hematopathology with an algorithm to diagnose the most common neoplasms is presented. We discuss precursor B-cell neoplasms, mature B-cell neoplasms (SLL/CLL, mantle cell lymphoma, marginal zone lymphoma, hairy cell leukemia, diffuse large B-cell lymphoma, plasma cell dyscrasias and lymphomas with plasmacytic differentiation), precursor T-lymphoblastic leukemia and mature (peripheral) T-cell neoplasms, including T-SLL/PLL, anaplastic cell lymphomas and large granular cell leukemia/lymphoma. The text is accompanied by characteristic FC scatterplots of the discussed entities.

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Dec 2000
Volume 17 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Weisberger J, Wu C, Liu Z, Wong J, Melamed M, Darzynkiewicz Z and Gorczyca W: Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).. Int J Oncol 17: 1165-1242, 2000.
APA
Weisberger, J., Wu, C., Liu, Z., Wong, J., Melamed, M., Darzynkiewicz, Z., & Gorczyca, W. (2000). Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).. International Journal of Oncology, 17, 1165-1242. https://doi.org/10.3892/ijo.17.6.1165
MLA
Weisberger, J., Wu, C., Liu, Z., Wong, J., Melamed, M., Darzynkiewicz, Z., Gorczyca, W."Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).". International Journal of Oncology 17.6 (2000): 1165-1242.
Chicago
Weisberger, J., Wu, C., Liu, Z., Wong, J., Melamed, M., Darzynkiewicz, Z., Gorczyca, W."Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review).". International Journal of Oncology 17, no. 6 (2000): 1165-1242. https://doi.org/10.3892/ijo.17.6.1165