Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.

  • Authors:
    • H Takahashi
    • Y Maeda
    • K Watanabe
    • K Taguchi
    • F Sasaki
    • S Todo
  • View Affiliations

  • Published online on: December 1, 2000     https://doi.org/10.3892/ijo.17.6.1205
  • Pages: 1205-1216
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Abstract

We determined intratumoral thymidine phosphorylase (dThdPase) activity in 213 patients with T2N0M0 or T2N1M0 breast cancer. After surgery doxifluridine, an intermediate metabolite of capecitabine, and tamoxifen were given by mouth. According to dThdPase activity the examined patients were classified as: A, high activity group; tumors with the activity not less than the mean value and B, low activity group; tumors with activity less than the mean value. Group A had a better prognosis than group B in node-positive patients (disease-free survival, p=0.0446; overall survival, p=0.0788). Intratumoral dThdPase activity might be a useful marker for predicting responsiveness to doxifluridine treatment in the adjuvant setting.

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Dec 2000
Volume 17 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takahashi H, Maeda Y, Watanabe K, Taguchi K, Sasaki F and Todo S: Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.. Int J Oncol 17: 1205-1216, 2000.
APA
Takahashi, H., Maeda, Y., Watanabe, K., Taguchi, K., Sasaki, F., & Todo, S. (2000). Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.. International Journal of Oncology, 17, 1205-1216. https://doi.org/10.3892/ijo.17.6.1205
MLA
Takahashi, H., Maeda, Y., Watanabe, K., Taguchi, K., Sasaki, F., Todo, S."Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.". International Journal of Oncology 17.6 (2000): 1205-1216.
Chicago
Takahashi, H., Maeda, Y., Watanabe, K., Taguchi, K., Sasaki, F., Todo, S."Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.". International Journal of Oncology 17, no. 6 (2000): 1205-1216. https://doi.org/10.3892/ijo.17.6.1205