search button

Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer

  • Authors:
    • Tsutomu Kawakami
    • Tetsuji Tokunaga
    • Hiroyuki Hatanaka
    • Takashi Tsuchida
    • Yasushi Tomii
    • Hideo Osada
    • Noboru Onoda
    • Fumitoshi Morino
    • Junko Nagata
    • Hiroshi Kijima
    • Hitoshi Yamazaki
    • Yoshiyuki Abe
    • Yoshiyuki Osamura
    • Yoshito Ueyama
    • Masato Nakamura

  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/ijo.18.3.487
  • Pages: 487-491
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Interleukin 10 (IL-10) is an immuno-suppressive cytokine produced by T-lymphocytes, and a regulatory molecule for angiogenesis in various cancers. We examined IL-10 gene expression in 53 colon cancer patients who underwent surgical resection. IL-10 gene expression was correlated with TSP1 and TSP2 gene expression (P=0.0049, P=0.0285). Colon cancer with IL-10 gene expression (19/53) showed significantly decreased venous involvement (P=0.0433). The mean vessel counts in the colon cancers with IL-10 gene expression were significantly lower than those without IL-10 gene expression (P<0.001). These results suggested that IL-10 stimulates angiostatic factor gene expression, and results in suppression of venous involvement.

Related Articles

Journal Cover

March 2001
Volume 18 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Kawakami T, Tokunaga T, Hatanaka H, Tsuchida T, Tomii Y, Osada H, Onoda N, Morino F, Nagata J, Kijima H, Kijima H, et al: Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer. Int J Oncol 18: 487-491, 2001
APA
Kawakami, T., Tokunaga, T., Hatanaka, H., Tsuchida, T., Tomii, Y., Osada, H. ... Nakamura, M. (2001). Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer. International Journal of Oncology, 18, 487-491. https://doi.org/10.3892/ijo.18.3.487
MLA
Kawakami, T., Tokunaga, T., Hatanaka, H., Tsuchida, T., Tomii, Y., Osada, H., Onoda, N., Morino, F., Nagata, J., Kijima, H., Yamazaki, H., Abe, Y., Osamura, Y., Ueyama, Y., Nakamura, M."Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer". International Journal of Oncology 18.3 (2001): 487-491.
Chicago
Kawakami, T., Tokunaga, T., Hatanaka, H., Tsuchida, T., Tomii, Y., Osada, H., Onoda, N., Morino, F., Nagata, J., Kijima, H., Yamazaki, H., Abe, Y., Osamura, Y., Ueyama, Y., Nakamura, M."Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer". International Journal of Oncology 18, no. 3 (2001): 487-491. https://doi.org/10.3892/ijo.18.3.487