Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors

  • Authors:
    • Zineb Gaci
    • Marie-Helene Bouin-Pineau
    • Mohammed Gaci
    • Alain Daban
    • Pierre Ingrand
    • Thierry Metaye
  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.793
  • Pages: 793-800
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Abstract

Some node-negative breast cancer patients, with initially good prognosis, relapse from their cancer and are poorly identified. In the present study, based on prospective data of 197 tumors, we measured cathepsin D (cath D, n=197), pS2 protein (n=125), c-erbB-2 oncoprotein (n=100) and epidermal growth factor receptor (EGF-R, n=99) to better define the risk of relapse of node-negative patients in comparison with that defined by the clinical and histological factors. The median follow-up in surviving patients was 75 months. Univariate analysis indicated that patients with histological grade III tumors (the Scarff, Bloom and Richardson classification) had a much poorer prognosis than those with histological grade I or II tumors (P=0.0027 for relapse-free survival and P=0.0156 for overall survival). When the population of node-negative patients was divided by tertiles, high cath D levels showed a significant association with an early relapse (P=0.0316). Using cut-off values, patients with high cath D (≥25 pmol/mg protein) or c-erbB-2 oncoprotein (≥4 Human Neu Unit/μg protein) levels, had a significant worse relapse-free survival (P=0.0147 and 0.0417, respectively). No prognostic information was supported by pS2 protein or EGF-R measurements. In multivariate analysis, histological grade, cath D and c-erbB-2 oncoprotein remained independent predictors of recurrence (P=0.005, 0.0361 and 0.0321, respectively). By combining low levels of cath D and c-erbB-2 oncoprotein in histological grade I or II tumors, we identified a subgroup of patients with a 100% relapse-free survival probability at 6 years of follow-up. Moreover, the subgroup of patients with histological grade I or II tumors and high values of both cath D and c-erbB-2 oncoprotein showed a prognosis as poor as the subgroup defined by histological grade III alone, respectively 66% and 70% relapse-free survival at 6 years of follow-up. In conclusion, the combination of conventional prognostic factor (histological grade) and biochemical factors (cath D and c-erbB-2 oncoprotein) enabled us to identify, in this preliminary study, a subgroup of patients having an increased risk of relapse in a group (node-negative patients with low histological grade tumors) considered as good prognosis.

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April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Gaci, Z., Bouin-Pineau, M., Gaci, M., Daban, A., Ingrand, P., & Metaye, T. (2001). Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors. International Journal of Oncology, 18, 793-800. https://doi.org/10.3892/ijo.18.4.793
MLA
Gaci, Z., Bouin-Pineau, M., Gaci, M., Daban, A., Ingrand, P., Metaye, T."Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors". International Journal of Oncology 18.4 (2001): 793-800.
Chicago
Gaci, Z., Bouin-Pineau, M., Gaci, M., Daban, A., Ingrand, P., Metaye, T."Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors". International Journal of Oncology 18, no. 4 (2001): 793-800. https://doi.org/10.3892/ijo.18.4.793