Significance of integrin α2/β1 in peritoneal dissemination of a human gastric cancer xenograft model
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- Published online on: April 1, 2001 https://doi.org/10.3892/ijo.18.4.809
- Pages: 809-815
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Abstract
In the present study, the role of integrin α2/β1 in peritoneal dissemination of gastric cancer was investigated using an in vivo xenograft model for the highly metastatic MKN-45-P gastric cancer cells. Metastatic ability of MKN-45-P cells was significantly associated with the simultaneous expression of integrin α2 and α3 subunits. In an in vitro adhesion assay, neutralizing antibody for integrin α2 or β1 subunit inhibited the adhesion of MKN-45-P cells to collagen type I and type IV. Moreover, the injection of anti-β1 monoclonal antibody reduced the number of cancer cells on the peritoneum in nude mice that had been inoculated with MKN-45-P cells. These results suggest that integrin α2/β1 represents a candidate target molecule available for the prevention of gastric cancer peritoneal dissemination.
