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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2001 Volume 18 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2001 Volume 18 Issue 6

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Article

Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation

  • Authors:
    • D.-X. Hou
    • M. Fukuda
    • J. A. Johnson
    • K. Miyamori
    • M. Ushikai
    • M. Fujii

  • View Affiliations / Copyright

    Affiliations: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan
  • Pages: 1175-1179
    |
    Published online on: June 1, 2001
       https://doi.org/10.3892/ijo.18.6.1175
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Abstract

Induction of phase II enzymes such as NADPH:quinone oxidoreductase (QR) can reduce carcinogen-induced mutagenesis and tumor formation. In our search for novel dietary anticarcinogens, fisetin, a flavonol widely distributed in fruits and vegetables was found to induce QR activity in murine hepatoma 1c1c7 cells. The cells were treated with various concentrations of fisetin, and then were assessed for cell growth, QR activity, QR mRNA expression and transcription activation of the QR gene. The results showed that fisetin induced QR activity in time- and dose-dependent manner in the concentration range of 0.1 to 10 μM, and the activity induction was associated with QR mRNA expression as detected by reverse transcription-PCR. Furthermore, transfection studies using a human QR antioxidant/electrophile-response element (ARE/EpRE) reporter construct demonstrated that fisetin activated the ARE/EpRE. These results show that fisetin increases QR activity by transcriptional activation of the ARE/EpRE, suggesting a novel mechanism by which dietary fisetin may be implicated in cancer chemoprevention.

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Copy and paste a formatted citation
Spandidos Publications style
Hou D, Fukuda M, Johnson JA, Miyamori K, Ushikai M and Fujii M: Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. Int J Oncol 18: 1175-1179, 2001.
APA
Hou, D., Fukuda, M., Johnson, J.A., Miyamori, K., Ushikai, M., & Fujii, M. (2001). Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. International Journal of Oncology, 18, 1175-1179. https://doi.org/10.3892/ijo.18.6.1175
MLA
Hou, D., Fukuda, M., Johnson, J. A., Miyamori, K., Ushikai, M., Fujii, M."Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation". International Journal of Oncology 18.6 (2001): 1175-1179.
Chicago
Hou, D., Fukuda, M., Johnson, J. A., Miyamori, K., Ushikai, M., Fujii, M."Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation". International Journal of Oncology 18, no. 6 (2001): 1175-1179. https://doi.org/10.3892/ijo.18.6.1175
Copy and paste a formatted citation
x
Spandidos Publications style
Hou D, Fukuda M, Johnson JA, Miyamori K, Ushikai M and Fujii M: Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. Int J Oncol 18: 1175-1179, 2001.
APA
Hou, D., Fukuda, M., Johnson, J.A., Miyamori, K., Ushikai, M., & Fujii, M. (2001). Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation. International Journal of Oncology, 18, 1175-1179. https://doi.org/10.3892/ijo.18.6.1175
MLA
Hou, D., Fukuda, M., Johnson, J. A., Miyamori, K., Ushikai, M., Fujii, M."Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation". International Journal of Oncology 18.6 (2001): 1175-1179.
Chicago
Hou, D., Fukuda, M., Johnson, J. A., Miyamori, K., Ushikai, M., Fujii, M."Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation". International Journal of Oncology 18, no. 6 (2001): 1175-1179. https://doi.org/10.3892/ijo.18.6.1175
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