The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat

  • Authors:
    • Ulrich Pfeffer
    • Paola Ferro
    • Valentina Pavia
    • Sonya Trombino
    • Raffaella Dell'Eva
    • Giorgio Merlo
    • Giovanni Levi
  • View Affiliations

  • Published online on: June 1, 2001     https://doi.org/10.3892/ijo.18.6.1293
  • Pages: 1293-1297
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Abstract

The region on chromosome 7q21-22 is frequently altered in several human neoplasias such as uterine leiomyoma, myeloid leukemia and breast cancer. The same region has also been linked to split hand/split foot malformation type 1 and to involutional osteoporosis. Our analysis of genes that map to this region has led to the identification of the so far unknown first exon of the homeobox gene DLX6, a mammalian homologue of the Drosophila distal-less gene. Distal-less is a downstream target of the trithorax transcription factors. Translocations involving the mammalian homologue of trithorax, ALL-1, leading to its constitutive activation cause leukemia. We describe here that the first exons of human and mouse DLX6 genes contain a multiple trinucleotide repeat region. We have analyzed the CAG repeat length in 90 subjects and were able to identify five alleles with 11 to 20 CAG repeats.

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June 2001
Volume 18 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Pfeffer U, Ferro P, Pavia V, Trombino S, Dell'Eva R, Merlo G and Levi G: The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. Int J Oncol 18: 1293-1297, 2001.
APA
Pfeffer, U., Ferro, P., Pavia, V., Trombino, S., Dell'Eva, R., Merlo, G., & Levi, G. (2001). The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. International Journal of Oncology, 18, 1293-1297. https://doi.org/10.3892/ijo.18.6.1293
MLA
Pfeffer, U., Ferro, P., Pavia, V., Trombino, S., Dell'Eva, R., Merlo, G., Levi, G."The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat". International Journal of Oncology 18.6 (2001): 1293-1297.
Chicago
Pfeffer, U., Ferro, P., Pavia, V., Trombino, S., Dell'Eva, R., Merlo, G., Levi, G."The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat". International Journal of Oncology 18, no. 6 (2001): 1293-1297. https://doi.org/10.3892/ijo.18.6.1293