Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer

  • Authors:
    • I. Nozaki
    • T. Tsuji
    • O. Iijima
    • Y. Ohmura
    • A. Andou
    • M. Miyazaki
    • N. Shimizu
    • M. Namba
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/ijo.19.1.117
  • Pages: 117-121
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Abstract

Dickkopfs (Dkks) are secretory glycoproteins and are important for inducing amphibian head formation. Some Dkks have the ability to antagonize the Wnt proto-oncoprotein, which can promote cell proliferation and transformation when it is mutated or overexpressed. We recently cloned the REIC/Dkk-3 gene, one of the Dkks, and found that expression of the gene was markedly decreased in many human immortalized and tumor-derived cell lines. To further investigate the function of the REIC/Dkk-3 gene in vivo, the gene expression was quantified in 57 surgically-resected non-small cell lung cancer (NSCLC) tissues and their adjacent normal lung tissues by real-time quantitative PCR analysis based on TaqMan methodology. The REIC/Dkk-3 mRNA level was significantly lower in NSCLC tissues than in normal lung tissues. Reduced expression of REIC/Dkk-3 in NSCLC was observed in 36 (63%) of the 57 tumors. Reduced expression of REIC/Dkk-3 was frequently observed in poorly differentiated adenocarcinoma and squamous cell carcinoma. These results indicate that reduced expression of REIC/Dkk-3 may be correlated with rapid cell proliferation in human NSCLC.

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July 2001
Volume 19 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nozaki, I., Tsuji, T., Iijima, O., Ohmura, Y., Andou, A., Miyazaki, M. ... Namba, M. (2001). Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer. International Journal of Oncology, 19, 117-121. https://doi.org/10.3892/ijo.19.1.117
MLA
Nozaki, I., Tsuji, T., Iijima, O., Ohmura, Y., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer". International Journal of Oncology 19.1 (2001): 117-121.
Chicago
Nozaki, I., Tsuji, T., Iijima, O., Ohmura, Y., Andou, A., Miyazaki, M., Shimizu, N., Namba, M."Reduced expression of REIC/Dkk-3 gene in non-small cell lung cancer". International Journal of Oncology 19, no. 1 (2001): 117-121. https://doi.org/10.3892/ijo.19.1.117