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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2001 Volume 19 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 19 Issue 2

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Article

S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells

  • Authors:
    • Andrea Manni
    • Stephen Fischer
    • Matthew Franks
    • Sharlene Washington
    • Rena De Arment
    • James Griffith
    • Laurence Demers
    • Michael Verderame
    • Benjamin Leiby
    • David Mauger
  • View Affiliations / Copyright

    Affiliations: Division of Endocrinology, H044 Hershey Medical Center, Hershey, PA 17033-0850, USA
  • Pages: 317-323
    |
    Published online on: August 1, 2001
       https://doi.org/10.3892/ijo.19.2.317
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Abstract

To elucidate the role of S-adenosylmethionine decarboxylase (SAMDC) in breast cancer biology, we have generated SAMDC overexpressing MCF-7 breast cancer cells. SAMDC overexpression did not alter in a major way growth properties of MCF-7 cells in soft agar, either under basal conditions or in response to estrogen and antiestrogen administration. SAMDC-MCF-7 cells, on the other hand, exhibited a markedly reduced invasive ability in matrigel (p=0.013). Furthermore, they were less tumorigenic in nude mice. The odds for control clones to form tumors were 3.13 (C.1.1.2-8.2, p=0.0184) higher than those for SAMDC clones. The odds ratio were identical in the absence and in the presence of estradiol. In addition, the growth rate of established tumors was slower for SAMDC than for control clones. Overall, our results are consistent with the notion that these phenotypic changes induced by SAMDC overexpression are primarily mediated by suppression of cellular putrescine (and, possibly, spermidine) levels.

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Copy and paste a formatted citation
Spandidos Publications style
Manni A, Fischer S, Franks M, Washington S, De Arment R, Griffith J, Demers L, Verderame M, Leiby B, Mauger D, Mauger D, et al: S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. Int J Oncol 19: 317-323, 2001.
APA
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J. ... Mauger, D. (2001). S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. International Journal of Oncology, 19, 317-323. https://doi.org/10.3892/ijo.19.2.317
MLA
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J., Demers, L., Verderame, M., Leiby, B., Mauger, D."S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells". International Journal of Oncology 19.2 (2001): 317-323.
Chicago
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J., Demers, L., Verderame, M., Leiby, B., Mauger, D."S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells". International Journal of Oncology 19, no. 2 (2001): 317-323. https://doi.org/10.3892/ijo.19.2.317
Copy and paste a formatted citation
x
Spandidos Publications style
Manni A, Fischer S, Franks M, Washington S, De Arment R, Griffith J, Demers L, Verderame M, Leiby B, Mauger D, Mauger D, et al: S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. Int J Oncol 19: 317-323, 2001.
APA
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J. ... Mauger, D. (2001). S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. International Journal of Oncology, 19, 317-323. https://doi.org/10.3892/ijo.19.2.317
MLA
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J., Demers, L., Verderame, M., Leiby, B., Mauger, D."S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells". International Journal of Oncology 19.2 (2001): 317-323.
Chicago
Manni, A., Fischer, S., Franks, M., Washington, S., De Arment, R., Griffith, J., Demers, L., Verderame, M., Leiby, B., Mauger, D."S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells". International Journal of Oncology 19, no. 2 (2001): 317-323. https://doi.org/10.3892/ijo.19.2.317
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