Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits

  • Authors:
    • O. Ishiko
    • T. Sumi
    • H. Yoshida
    • Y. Hyun
    • S. Ogita
  • View Affiliations

  • Published online on: August 1, 2001     https://doi.org/10.3892/ijo.19.2.325
  • Pages: 325-329
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Although the mechanism of cancer cachexia is unknown, in previous studies we reported that cyclic plasma perfusion through non-coated charcoal was effective in preventing cancer cachexia. In the present study we investigated the effect of cyclic plasma perfusion on VX2 carcinoma. Sixteen tumor-bearing rabbits were divided into two groups: i) a group subjected to cyclic plasma perfusion (n=8, group PP) and ii) a group subjected to sham-perfusion (n=8, group SP), and changes in body weight, tumor size, and morphological findings were investigated. Body weight loss and tumor growth were significantly suppressed in group PP. The tumor cells in group PP showed apoptosis and a high Bax/Bcl-2 ratio, and the survival rate was significantly higher than in group SP. These results suggest that cyclic plasma perfusion is effective not only in preventing cancer cachexia but in suppressing tumor growth and improving outcome.

Related Articles

Journal Cover

August 2001
Volume 19 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ishiko O, Sumi T, Yoshida H, Hyun Y and Ogita S: Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits. Int J Oncol 19: 325-329, 2001
APA
Ishiko, O., Sumi, T., Yoshida, H., Hyun, Y., & Ogita, S. (2001). Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits. International Journal of Oncology, 19, 325-329. https://doi.org/10.3892/ijo.19.2.325
MLA
Ishiko, O., Sumi, T., Yoshida, H., Hyun, Y., Ogita, S."Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits". International Journal of Oncology 19.2 (2001): 325-329.
Chicago
Ishiko, O., Sumi, T., Yoshida, H., Hyun, Y., Ogita, S."Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits". International Journal of Oncology 19, no. 2 (2001): 325-329. https://doi.org/10.3892/ijo.19.2.325