TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion

  • Authors:
    • H. Teraoka
    • T. Sawada
    • Y. Yamashita
    • B. Nakata
    • M. Ohira
    • T. Ishikawa
    • H. Nishino
    • K. Hirakawa
  • View Affiliations

  • Published online on: October 1, 2001     https://doi.org/10.3892/ijo.19.4.709
  • Pages: 709-715
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Abstract

We investigated the effect of TGF-β1 on liver metastasis of pancreatic cancer using surgical specimens of pancreatic cancer and human pancreatic cancer cell lines Capan-2 and SW1990. Immunostaining of TGF-β1 showed that TGF-β1 positivity was significantly related to venous invasion and tumor staging, and also relatively associated with liver metastasis. Cellular invasion and protease production of MMP-2 and u-PA, and in vivo liver metastasis were significantly enhanced after treatment of cells with TGF-β1. These findings suggest that TGF-β1 might play an important role in enhancing liver metastasis of pancreatic cancer.

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October 2001
Volume 19 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Teraoka H, Sawada T, Yamashita Y, Nakata B, Ohira M, Ishikawa T, Nishino H and Hirakawa K: TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. Int J Oncol 19: 709-715, 2001
APA
Teraoka, H., Sawada, T., Yamashita, Y., Nakata, B., Ohira, M., Ishikawa, T. ... Hirakawa, K. (2001). TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion. International Journal of Oncology, 19, 709-715. https://doi.org/10.3892/ijo.19.4.709
MLA
Teraoka, H., Sawada, T., Yamashita, Y., Nakata, B., Ohira, M., Ishikawa, T., Nishino, H., Hirakawa, K."TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion". International Journal of Oncology 19.4 (2001): 709-715.
Chicago
Teraoka, H., Sawada, T., Yamashita, Y., Nakata, B., Ohira, M., Ishikawa, T., Nishino, H., Hirakawa, K."TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion". International Journal of Oncology 19, no. 4 (2001): 709-715. https://doi.org/10.3892/ijo.19.4.709