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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2001 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2001 Volume 19 Issue 4

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Article

Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma

  • Authors:
    • Yong-Koo Park
    • Chang Hyun Cho
    • Sung Gil Chi
    • Chung Soo Han
    • Shinichiro Ushigome
    • K. Krishnan Unni

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Kyung Hee University Hospital, Seoul 130-702, Korea
  • Pages: 749-753
    |
    Published online on: October 1, 2001
       https://doi.org/10.3892/ijo.19.4.749
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Abstract

Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a quantitative DNA/PCR, PCR-SSCP. Two of 38 specimens (5.2%) we analyzed showed abnormally low levels of p16CDKN2a amplification, suggesting that the allelic deletion of the gene might be low frequent event in progression of this tumor. For detection of subtle sequence alterations such as point mutations, we performed SSCP analysis of the entire coding region of the p16CDKN2a gene. No altered SSCP patterns were found in 38 clear cell chondrosarcoma specimens. This study reflects the very low incidence of genetic alterations of the p16CDKN2a gene in clear cell chondrosarcoma. Therefore, we conclude that the alteration of the p16CDKN2a gene is not involved significantly in the development of clear cell chondrosarcoma.

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Copy and paste a formatted citation
Spandidos Publications style
Park Y, Cho CH, Chi SG, Han CS, Ushigome S and Unni KK: Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma. Int J Oncol 19: 749-753, 2001.
APA
Park, Y., Cho, C.H., Chi, S.G., Han, C.S., Ushigome, S., & Unni, K.K. (2001). Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma. International Journal of Oncology, 19, 749-753. https://doi.org/10.3892/ijo.19.4.749
MLA
Park, Y., Cho, C. H., Chi, S. G., Han, C. S., Ushigome, S., Unni, K. K."Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma". International Journal of Oncology 19.4 (2001): 749-753.
Chicago
Park, Y., Cho, C. H., Chi, S. G., Han, C. S., Ushigome, S., Unni, K. K."Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma". International Journal of Oncology 19, no. 4 (2001): 749-753. https://doi.org/10.3892/ijo.19.4.749
Copy and paste a formatted citation
x
Spandidos Publications style
Park Y, Cho CH, Chi SG, Han CS, Ushigome S and Unni KK: Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma. Int J Oncol 19: 749-753, 2001.
APA
Park, Y., Cho, C.H., Chi, S.G., Han, C.S., Ushigome, S., & Unni, K.K. (2001). Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma. International Journal of Oncology, 19, 749-753. https://doi.org/10.3892/ijo.19.4.749
MLA
Park, Y., Cho, C. H., Chi, S. G., Han, C. S., Ushigome, S., Unni, K. K."Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma". International Journal of Oncology 19.4 (2001): 749-753.
Chicago
Park, Y., Cho, C. H., Chi, S. G., Han, C. S., Ushigome, S., Unni, K. K."Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma". International Journal of Oncology 19, no. 4 (2001): 749-753. https://doi.org/10.3892/ijo.19.4.749
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