DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance

  • Authors:
    • Monika Schindl
    • Georg Oberhuber
    • Ernest G. Pichlbauer
    • Andreas Obermair
    • Peter Birner
    • Mark R. Kelley
  • View Affiliations

  • Published online on: October 1, 2001     https://doi.org/10.3892/ijo.19.4.799
  • Pages: 799-802
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Abstract

The multifunctional apurinic/apyrimidinic endonuclease (Ape1/ref-1) plays a key role in the human DNA base excision repair pathway. Ape1/ref-1 has also been shown to be involved in the redox control of transactivation activities of hypoxia-inducible factor (HIF)-1α. The aim of our study was to investigate the expression of these proteins in early stage invasive cervical cancer. Expression of Ape1/ref-1 and HIF-1α was detected immunohistochemically in 88 samples of cervical cancer stage pT1b. The levels of the proteins were compared and the prognostic influence of Ape1/ref-1 expression was investigated. Strong nuclear expression of Ape1/ref-1 was observed in 9 cases (10.2%), moderate in 22 cases (25%), weak in 17 cases (19.3%), and absent in 40 cases (45.5%). Furthermore, no correlation between Ape1/ref-1 and HIF-1α expression was observed (p=0.864). We also found no relationship of Ape1/ref-1 expression and survival (p>0.05, log-rank test). From these studies, we have concluded that in cervical cancer there is no correlation between the upstream redox regulatory protein of HIF-1, i.e., Ape1/ref-1, and HIF-1α expression. However, these studies do not address any functional relationship between the two proteins.

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October 2001
Volume 19 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P and Kelley MR: DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. Int J Oncol 19: 799-802, 2001.
APA
Schindl, M., Oberhuber, G., Pichlbauer, E.G., Obermair, A., Birner, P., & Kelley, M.R. (2001). DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance. International Journal of Oncology, 19, 799-802. https://doi.org/10.3892/ijo.19.4.799
MLA
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19.4 (2001): 799-802.
Chicago
Schindl, M., Oberhuber, G., Pichlbauer, E. G., Obermair, A., Birner, P., Kelley, M. R."DNA repair-redox enzyme apurinic endonuclease in cervical cancer: Evaluation of redox control of HIF-1α and prognostic significance". International Journal of Oncology 19, no. 4 (2001): 799-802. https://doi.org/10.3892/ijo.19.4.799