Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus

  • Authors:
    • Kuniyasu Murahashi
    • Masakazu Yashiro
    • Chiemi Takenaka
    • Tasuku Matsuoka
    • Masaichi Ohira
    • Kosei Hirakawa-YS Chung
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/ijo.19.5.1029
  • Pages: 1029-1033
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Abstract

Scirrhous gastric carcinoma, characterized by carcinoma cell proliferation and infiltration with extensive fibrosis in the stroma, frequently causes peritoneal metastasis. We describe here a newly established cell line, OCUM-6, derived from ascites effusion of a scirrhous gastric cancer patient. The cells are floating and round shape, similar to other scirrhous gastric carcinoma cell lines previously reported. Histologic findings of xenografted tumor obtained from OCUM-6 cells showed medullary growth with a poorly differentiated adenocarcinoma containing signet ring cells. LOH at E-cadherin locus 16q22 was observed in the OCUM-6 cells. LOH at E-cadherin locus might be closely associated with histologic findings and metastatic process of scirrhous gastric cancer. The scirrhous gastric cancer cell line, OCUM-6, may be useful for investigation of the mechanisms of peritoneal dissemination and carcinogenesis.

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November 2001
Volume 19 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Murahashi K, Yashiro M, Takenaka C, Matsuoka T, Ohira M and Hirakawa-YS Chung K: Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus. Int J Oncol 19: 1029-1033, 2001.
APA
Murahashi, K., Yashiro, M., Takenaka, C., Matsuoka, T., Ohira, M., & Hirakawa-YS Chung, K. (2001). Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus. International Journal of Oncology, 19, 1029-1033. https://doi.org/10.3892/ijo.19.5.1029
MLA
Murahashi, K., Yashiro, M., Takenaka, C., Matsuoka, T., Ohira, M., Hirakawa-YS Chung, K."Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus". International Journal of Oncology 19.5 (2001): 1029-1033.
Chicago
Murahashi, K., Yashiro, M., Takenaka, C., Matsuoka, T., Ohira, M., Hirakawa-YS Chung, K."Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus". International Journal of Oncology 19, no. 5 (2001): 1029-1033. https://doi.org/10.3892/ijo.19.5.1029