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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2001 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2001 Volume 19 Issue 5

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Article

Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer

  • Authors:
    • Bu-Kyu Lee
    • Elke Diebel
    • Friedrich Wilhelm Neukam
    • Jorg Wiltfang
    • Jutta Ries

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Cranio-Maxillofacial Surgery, University of Erlangen, D-90541 Erlangen, Germany
  • Pages: 1063-1068
    |
    Published online on: November 1, 2001
       https://doi.org/10.3892/ijo.19.5.1063
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Abstract

Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnostic and prognostic markers in oral cancer, we examined TA, hTR, hTP1 and hTERT mRNA expressions in 46 oral squamous cell carcinomas (OSCC) and 15 normal oral mucosal tissues from healthy volunteers using a highly sensitive TRAP assay and RT PCR. In all specimens hTR and hTP1 mRNA were detected regardless whether TA was expressed or not. On the contrary, a significant correlation between hTERT expression and TA was shown indicating that the activity of telomerase could be regulated by the extent of hTERT transcription. In addition, hTERT expression showed close association to malignancies. None of the normal mucosal specimens expressed the hTERT subunit, but 76% (35/46) of the tumor specimens did. None of other clinico-pathological and prognostic parameters showed significant relationship with TA or hTERT expression. These results suggest that the detection of hTERT expression may be another useful diagnostic marker, especially for early detection of OSCC, and for distinguishing healthy tissues from neoplastically transformed ones.

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Copy and paste a formatted citation
Spandidos Publications style
Lee B, Diebel E, Neukam FW, Wiltfang J and Ries J: Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. Int J Oncol 19: 1063-1068, 2001.
APA
Lee, B., Diebel, E., Neukam, F.W., Wiltfang, J., & Ries, J. (2001). Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. International Journal of Oncology, 19, 1063-1068. https://doi.org/10.3892/ijo.19.5.1063
MLA
Lee, B., Diebel, E., Neukam, F. W., Wiltfang, J., Ries, J."Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer". International Journal of Oncology 19.5 (2001): 1063-1068.
Chicago
Lee, B., Diebel, E., Neukam, F. W., Wiltfang, J., Ries, J."Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer". International Journal of Oncology 19, no. 5 (2001): 1063-1068. https://doi.org/10.3892/ijo.19.5.1063
Copy and paste a formatted citation
x
Spandidos Publications style
Lee B, Diebel E, Neukam FW, Wiltfang J and Ries J: Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. Int J Oncol 19: 1063-1068, 2001.
APA
Lee, B., Diebel, E., Neukam, F.W., Wiltfang, J., & Ries, J. (2001). Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. International Journal of Oncology, 19, 1063-1068. https://doi.org/10.3892/ijo.19.5.1063
MLA
Lee, B., Diebel, E., Neukam, F. W., Wiltfang, J., Ries, J."Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer". International Journal of Oncology 19.5 (2001): 1063-1068.
Chicago
Lee, B., Diebel, E., Neukam, F. W., Wiltfang, J., Ries, J."Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer". International Journal of Oncology 19, no. 5 (2001): 1063-1068. https://doi.org/10.3892/ijo.19.5.1063
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