AMPLIFICATION OF THE EXPRESSION OF MAJOR HISTOCOMPATIBILITY CLASS-I ANTIGENS BY INDUCERS OF DIFFERENTIATION AND GAMMA INTERFERON IN MURINE AND HUMAN SOLID TUMOR-CELL LINES
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- Published online on: February 1, 1993 https://doi.org/10.3892/ijo.2.2.279
- Pages: 279-282
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Abstract
Treatment of B16 F10-9 mouse melanoma cell line and RC-29 human renal carcinoma cell line with chemical inducers of differentiation such as sodium butyrate (SB) hexamethylene bisacetamide (HMBA) and L-histidinol significantly increased the expression of major histocompatability complex (MHC) class I antigens. This effect depends on the continued exposure of the cells to these materials. Combined treatment of the B16 F10-9 melanoma cells with recombinant murine gamma interferon and SB increased the expression of MHC class I antigens in a synergistic manner. This effect of chemical inducers of differentiation might be of importance in rendering tumor cells more sensitive to the immune defense mechanisms.
