VARIABLE REGION GENE ANALYSIS OF 2 HUMAN MONOCLONAL-ANTIBODIES TO GD3

  • Authors:
    • T ICHIHASHI
    • H YAMAGUCHI
    • K FURUKAWA
    • H SHIKU
    • T NAOE
    • R OHNO
  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.483
  • Pages: 483-491
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Abstract

We analyzed the genetic origins of anti-GD3 antibodies by comparing nucleotide sequences of the variable regions from the human monoclonal antibody (mAb), 27-26 (mu, k), established from a patient with leukemia, and another human anti-GD3 mAb, HJM-1 (mu, lambda) derived from a patient with melanoma. The variable regions of 27-26 and HJM-1 were remarkably similar to the germ-line genes. The mAb 27-26 was thought to be derived from germ-line repertoire expanded throughout our experiment. HJM-1 was derived from lymphocytes stimulated by GD3 abundantly expressed on melanoma cells.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ICHIHASHI T, YAMAGUCHI H, FURUKAWA K, SHIKU H, NAOE T and OHNO R: VARIABLE REGION GENE ANALYSIS OF 2 HUMAN MONOCLONAL-ANTIBODIES TO GD3. Int J Oncol 2: 483-491, 1993
APA
ICHIHASHI, T., YAMAGUCHI, H., FURUKAWA, K., SHIKU, H., NAOE, T., & OHNO, R. (1993). VARIABLE REGION GENE ANALYSIS OF 2 HUMAN MONOCLONAL-ANTIBODIES TO GD3. International Journal of Oncology, 2, 483-491. https://doi.org/10.3892/ijo.2.4.483
MLA
ICHIHASHI, T., YAMAGUCHI, H., FURUKAWA, K., SHIKU, H., NAOE, T., OHNO, R."VARIABLE REGION GENE ANALYSIS OF 2 HUMAN MONOCLONAL-ANTIBODIES TO GD3". International Journal of Oncology 2.4 (1993): 483-491.
Chicago
ICHIHASHI, T., YAMAGUCHI, H., FURUKAWA, K., SHIKU, H., NAOE, T., OHNO, R."VARIABLE REGION GENE ANALYSIS OF 2 HUMAN MONOCLONAL-ANTIBODIES TO GD3". International Journal of Oncology 2, no. 4 (1993): 483-491. https://doi.org/10.3892/ijo.2.4.483