In multicellular organisms, internal evolution of individual cells is strictly forbidden and 'evolutional' DNA replication should be performed only by the sexual reproduction system in these organisms, although in malignant tumors, it seems that individual cells replicate 'selfishly' and evolve against the internal micro-environment. This phenomenon is based on the failure of identical DNA replication, and results in 'anomie' of cellular society. Genetic programs of normal cells connote this cellular anomie, since they are introduced by the deletion of regulators on structure genes and cells have clearly been evolved from 'monads' in which cells proliferate without regulation. Tumor heterogeneity and progression can be fully explained by this self-contradictory process which produces heterogeneous gene copies different from the original clone in the tumor, although 'selfish' gene replication is the final target of being.

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