PROGNOSTIC-SIGNIFICANCE OF P53 AND C-ERBB-2 EXPRESSION IN OPERABLE BREAST-CANCER

  • Authors:
    • M NOGUCHI
    • H KITAGAWA
    • K KINOSHITA
    • I MIYAZAKI
    • Y SAITO
    • Y MIZUKAMI
  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.587
  • Pages: 587-591
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Abstract

We analyzed associations among p53 and c-erbB-2 expression and clinicopathologic variables and, then ascertained whether p53 and/or c-erbB-2 expression would be useful for estimating prognosis in 105 breast cancer patients. There was no significant association between p53 and c-erbB-2 expression, but the combination of p53 and c-erbB-2 expression was significantly associated with axillary lymph node metastases. Although both p53 and c-erbB-2 expressions were significant prognostic factors by univariate analysis, they did not appear to be independent prognostic factors by multivariate analysis in which nodal status was introduced using the Cox model. When nodal status was excluded, however, p53 and c-erbB-2 expression each had independent prognostic value.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
NOGUCHI M, KITAGAWA H, KINOSHITA K, MIYAZAKI I, SAITO Y and MIZUKAMI Y: PROGNOSTIC-SIGNIFICANCE OF P53 AND C-ERBB-2 EXPRESSION IN OPERABLE BREAST-CANCER. Int J Oncol 2: 587-591, 1993
APA
NOGUCHI, M., KITAGAWA, H., KINOSHITA, K., MIYAZAKI, I., SAITO, Y., & MIZUKAMI, Y. (1993). PROGNOSTIC-SIGNIFICANCE OF P53 AND C-ERBB-2 EXPRESSION IN OPERABLE BREAST-CANCER. International Journal of Oncology, 2, 587-591. https://doi.org/10.3892/ijo.2.4.587
MLA
NOGUCHI, M., KITAGAWA, H., KINOSHITA, K., MIYAZAKI, I., SAITO, Y., MIZUKAMI, Y."PROGNOSTIC-SIGNIFICANCE OF P53 AND C-ERBB-2 EXPRESSION IN OPERABLE BREAST-CANCER". International Journal of Oncology 2.4 (1993): 587-591.
Chicago
NOGUCHI, M., KITAGAWA, H., KINOSHITA, K., MIYAZAKI, I., SAITO, Y., MIZUKAMI, Y."PROGNOSTIC-SIGNIFICANCE OF P53 AND C-ERBB-2 EXPRESSION IN OPERABLE BREAST-CANCER". International Journal of Oncology 2, no. 4 (1993): 587-591. https://doi.org/10.3892/ijo.2.4.587