MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT

  • Authors:
    • K BHATIA
    • G SPANGLER
    • S ADVANI
    • A KAMEL
    • N HAMDY
    • RS IYER
    • P APLAN
    • IT MAGRATH
  • View Affiliations

  • Published online on: May 1, 1993     https://doi.org/10.3892/ijo.2.5.725
  • Pages: 725-730
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Abstract

SCL gene rearrangement is the most common molecular lesion (25%) identified so far in T-cell acute lymphoblastic leukemia (T-ALL). Since the frequency of T-ALL appears to be relatively higher in developing countries, we wished to determine as to what fraction of T-ALL from this population harbor SCL rearrangements. We show in this study that although the overall frequency of SCL/SIL rearrangements in T-ALL is similar to the Western countries this is at the expense of increased type A rearrangements. Whether the paucity of type B rearrangements reflects a difference in disease etiology in this part of the world is to be determined.

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May 1993
Volume 2 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BHATIA K, SPANGLER G, ADVANI S, KAMEL A, HAMDY N, IYER R, APLAN P and MAGRATH I: MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT. Int J Oncol 2: 725-730, 1993.
APA
BHATIA, K., SPANGLER, G., ADVANI, S., KAMEL, A., HAMDY, N., IYER, R. ... MAGRATH, I. (1993). MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT. International Journal of Oncology, 2, 725-730. https://doi.org/10.3892/ijo.2.5.725
MLA
BHATIA, K., SPANGLER, G., ADVANI, S., KAMEL, A., HAMDY, N., IYER, R., APLAN, P., MAGRATH, I."MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT". International Journal of Oncology 2.5 (1993): 725-730.
Chicago
BHATIA, K., SPANGLER, G., ADVANI, S., KAMEL, A., HAMDY, N., IYER, R., APLAN, P., MAGRATH, I."MOLECULAR CHARACTERIZATION OF SCL REARRANGEMENTS IN T-CELL ALL FROM INDIA AND EGYPT". International Journal of Oncology 2, no. 5 (1993): 725-730. https://doi.org/10.3892/ijo.2.5.725