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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1993 Volume 2 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1993 Volume 2 Issue 6

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Article

SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER

  • Authors:
    • A JAMEEL
    • M LAW
    • RC COOMBES
    • YA LUQMANI

  • View Affiliations / Copyright

    Affiliations: CHARING CROSS HOSP,DEPT MED ONCOL,FULHAM PALACE RD,LONDON W6 8RF,ENGLAND. ROYAL CANC HOSP,INST CANC RES,EPIDEMIOL SECT,SUTTON SM2 5NG,SURREY,ENGLAND.
  • Pages: 1075-1080
    |
    Published online on: June 1, 1993
       https://doi.org/10.3892/ijo.2.6.1075
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Abstract

A human breast cancer cDNA library was screened with a polyclonal antiserum against breast cancer metastasis membranes in order to select genes whose expression may be altered in breast malignancy. Several immunopositive clones have been isolated. One of these, AJ1, was analyzed in detail and found to be expressed at varying levels as a 3.3 kb mRNA in all of the 123 primary breast cancers examined. AJ1 was expressed at lower levels in non-malignant biopsies as compared to malignant tissue (p=0.0008). We found high expression to be associated with lymph node involvement (p=0.059). Comparison between high and low expressing groups showed a significant difference for both overall (p=0.039) and relapse-free (p=0.034) survival at 10 years, with early recurrence and reduced overall survival in high expressors. Thus, AJ1 could be a potentially useful prognostic factor and marker of aggressiveness in breast cancer. Partial sequence analysis of the 620 bp clone showed complete homology with human heat shock protein, HSP 90.

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Copy and paste a formatted citation
Spandidos Publications style
JAMEEL A, LAW M, COOMBES R and LUQMANI Y: SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER. Int J Oncol 2: 1075-1080, 1993.
APA
JAMEEL, A., LAW, M., COOMBES, R., & LUQMANI, Y. (1993). SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER. International Journal of Oncology, 2, 1075-1080. https://doi.org/10.3892/ijo.2.6.1075
MLA
JAMEEL, A., LAW, M., COOMBES, R., LUQMANI, Y."SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER". International Journal of Oncology 2.6 (1993): 1075-1080.
Chicago
JAMEEL, A., LAW, M., COOMBES, R., LUQMANI, Y."SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER". International Journal of Oncology 2, no. 6 (1993): 1075-1080. https://doi.org/10.3892/ijo.2.6.1075
Copy and paste a formatted citation
x
Spandidos Publications style
JAMEEL A, LAW M, COOMBES R and LUQMANI Y: SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER. Int J Oncol 2: 1075-1080, 1993.
APA
JAMEEL, A., LAW, M., COOMBES, R., & LUQMANI, Y. (1993). SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER. International Journal of Oncology, 2, 1075-1080. https://doi.org/10.3892/ijo.2.6.1075
MLA
JAMEEL, A., LAW, M., COOMBES, R., LUQMANI, Y."SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER". International Journal of Oncology 2.6 (1993): 1075-1080.
Chicago
JAMEEL, A., LAW, M., COOMBES, R., LUQMANI, Y."SIGNIFICANCE OF HEAT-SHOCK PROTEIN-90 AS A PROGNOSTIC INDICATOR IN BREAST-CANCER". International Journal of Oncology 2, no. 6 (1993): 1075-1080. https://doi.org/10.3892/ijo.2.6.1075
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