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DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS

  • Authors:
    • M KOEZUKA
    • N KONDO
    • H KOBAYASHI
    • S HARA
    • M YASUTOMI
    • S NISHIDA
    • S HASHIMOTO
    • H ASANO

  • View Affiliations

  • Published online on: June 1, 1993     https://doi.org/10.3892/ijo.2.6.953
  • Pages: 953-959
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Abstract

A new drug sensitivity assay method using the collagen gel embedded culture and image analysis was developed. Human cancer cells cultured in collagen gels showed extremely high cloning efficiency and in vivo-like drug response. In addition, image analysis was used successfully for the first time to automatically discriminate cancer colonies from contaminating fibroblastic cells by taking advantage of the difference in shape between them after cultivation to determine the drug response of cultured cancer cells accurately and easily. A new approach for the practical use of the drug sensitivity test on human cancer cells is suggested.

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June 1993
Volume 2 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
KOEZUKA M, KONDO N, KOBAYASHI H, HARA S, YASUTOMI M, NISHIDA S, HASHIMOTO S and ASANO H: DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS. Int J Oncol 2: 953-959, 1993
APA
KOEZUKA, M., KONDO, N., KOBAYASHI, H., HARA, S., YASUTOMI, M., NISHIDA, S. ... ASANO, H. (1993). DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS. International Journal of Oncology, 2, 953-959. https://doi.org/10.3892/ijo.2.6.953
MLA
KOEZUKA, M., KONDO, N., KOBAYASHI, H., HARA, S., YASUTOMI, M., NISHIDA, S., HASHIMOTO, S., ASANO, H."DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS". International Journal of Oncology 2.6 (1993): 953-959.
Chicago
KOEZUKA, M., KONDO, N., KOBAYASHI, H., HARA, S., YASUTOMI, M., NISHIDA, S., HASHIMOTO, S., ASANO, H."DRUG SENSITIVITY TEST FOR PRIMARY CULTURE OF HUMAN CANCER-CELLS USING COLLAGEN GEL EMBEDDED CULTURE AND IMAGE-ANALYSIS". International Journal of Oncology 2, no. 6 (1993): 953-959. https://doi.org/10.3892/ijo.2.6.953