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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2002 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2002 Volume 20 Issue 3

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Article

Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization

  • Authors:
    • H. Bahia
    • J. N.E. Ashman
    • L. Cawkwell
    • M. Lind
    • J. R.T. Monson
    • P. J. Drew
    • J. Greenman

  • View Affiliations / Copyright

    Affiliations: Academic Surgical Unit, University of Hull, Castle Hill Hospital, Cottingham, East Yorks HU16 5JQ, UK
  • Pages: 489-494
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/ijo.20.3.489
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Abstract

The breast cancer cell line MCF-7 is a widely used model in breast cancer research however a number of conflicting reports have been published regarding its biological properties. We hypothesised that there will be significant in vitro mutation and genotypic evolution over time in this cell line. To assess the genetic divergence of MCF-7 at the chromosomal level, we analysed MCF-7 cell lines grown independently at three different laboratories using M-FISH and CGH. In addition, MCF-7 cells from our own laboratory were also analysed at two time points 18 months apart. Several common chromosomal translocations were identified in all variants of the cell lines. In addition, a significant number of unique abnormalities were identified, characterising each of the variants studied. Genotypic differences between cell lines grown independently in different laboratories would significantly alter the phenotypic characteristics of each cell line rendering biological properties inconsistent between laboratories.

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Copy and paste a formatted citation
Spandidos Publications style
Bahia H, Ashman JN, Cawkwell L, Lind M, Monson JR, Drew PJ and Greenman J: Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization. Int J Oncol 20: 489-494, 2002.
APA
Bahia, H., Ashman, J.N., Cawkwell, L., Lind, M., Monson, J.R., Drew, P.J., & Greenman, J. (2002). Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization. International Journal of Oncology, 20, 489-494. https://doi.org/10.3892/ijo.20.3.489
MLA
Bahia, H., Ashman, J. N., Cawkwell, L., Lind, M., Monson, J. R., Drew, P. J., Greenman, J."Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization". International Journal of Oncology 20.3 (2002): 489-494.
Chicago
Bahia, H., Ashman, J. N., Cawkwell, L., Lind, M., Monson, J. R., Drew, P. J., Greenman, J."Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization". International Journal of Oncology 20, no. 3 (2002): 489-494. https://doi.org/10.3892/ijo.20.3.489
Copy and paste a formatted citation
x
Spandidos Publications style
Bahia H, Ashman JN, Cawkwell L, Lind M, Monson JR, Drew PJ and Greenman J: Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization. Int J Oncol 20: 489-494, 2002.
APA
Bahia, H., Ashman, J.N., Cawkwell, L., Lind, M., Monson, J.R., Drew, P.J., & Greenman, J. (2002). Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization. International Journal of Oncology, 20, 489-494. https://doi.org/10.3892/ijo.20.3.489
MLA
Bahia, H., Ashman, J. N., Cawkwell, L., Lind, M., Monson, J. R., Drew, P. J., Greenman, J."Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization". International Journal of Oncology 20.3 (2002): 489-494.
Chicago
Bahia, H., Ashman, J. N., Cawkwell, L., Lind, M., Monson, J. R., Drew, P. J., Greenman, J."Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization". International Journal of Oncology 20, no. 3 (2002): 489-494. https://doi.org/10.3892/ijo.20.3.489
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