Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression

  • Authors:
    • Anne Cayre
    • Florent Cachin
    • Jean Maublant
    • Daniele Mestas
    • Viviane Feillel
    • Jean-Pierre Ferriere
    • Fabrice Kwiaktowski
    • Sylvie Chevillard
    • Francoise Finat-Duclos
    • Pierre Verrelle
    • Frederique Penault-Llorca
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/ijo.20.5.1049
  • Pages: 1049-1055
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Abstract

We examined the relevance of a pre-treatment single static view 99mTc-sestamibi scintimammography and expression of multidrug resistance proteins as predictors of response to neoadjuvant chemotherapy for invasive breast cancer. Forty-five patients affected by primary breast cancer underwent clinical examination, mammography, sonography, 99mTc-sestamibi scintimammography, and biopsy for histopathological diagnosis before neoadjuvant chemotherapy. Expression of MDR1 and MRP mRNA were determined by RT-PCR on fine-needle aspirations. Following completion of anthracycline-based chemotherapy, clinical, mammographic, sonographic and pathological responses were determined. 99mTc-sestamibi scintimammography predicted the reduction of tumor size measured by sonography and the pathological response according to Sataloff classification (p<0.05) and tend to predict pathological response according to Chevallier (p<0.1). A negative 99mTc-sestamibi scintimammography predicted chemoresistance with a specificity of 100%. Uptake of 99mTc-sestamibi was inversely correlated to the expression of MDR1 (p<0.05) in invasive ductal carcinoma. A pre-treatment single-view 99mTc-sestamibi scintimammography is an excellent predictor of MDR1 chemoresistance and was highly specific of a lack of pathological response to chemotherapy.

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May 2002
Volume 20 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Cayre A, Cachin F, Maublant J, Mestas D, Feillel V, Ferriere J, Kwiaktowski F, Chevillard S, Finat-Duclos F, Verrelle P, Verrelle P, et al: Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression. Int J Oncol 20: 1049-1055, 2002
APA
Cayre, A., Cachin, F., Maublant, J., Mestas, D., Feillel, V., Ferriere, J. ... Penault-Llorca, F. (2002). Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression. International Journal of Oncology, 20, 1049-1055. https://doi.org/10.3892/ijo.20.5.1049
MLA
Cayre, A., Cachin, F., Maublant, J., Mestas, D., Feillel, V., Ferriere, J., Kwiaktowski, F., Chevillard, S., Finat-Duclos, F., Verrelle, P., Penault-Llorca, F."Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression". International Journal of Oncology 20.5 (2002): 1049-1055.
Chicago
Cayre, A., Cachin, F., Maublant, J., Mestas, D., Feillel, V., Ferriere, J., Kwiaktowski, F., Chevillard, S., Finat-Duclos, F., Verrelle, P., Penault-Llorca, F."Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression". International Journal of Oncology 20, no. 5 (2002): 1049-1055. https://doi.org/10.3892/ijo.20.5.1049