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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Review

Epithelial ovarian cancer: Second and third line chemotherapy (Review)

  • Authors:
    • A. Latorre
    • M. De Lena
    • A. Catino
    • E. Crucitta
    • D. Sambiasi
    • M. Guida
    • A. Misino
    • V. Lorusso

  • View Affiliations / Copyright

    Affiliations: IRCCS-Oncology Hospital, I-70126 Bari, Italy
  • Pages: 179-186
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.179
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Abstract

Standard therapy for patients affected with advanced epithelial ovarian cancer is cytoreductive surgery followed by combination chemotherapy. With this treatment, most patients obtain clinical complete or partial response, nevertheless, relapse is common and salvage chemotherapy is often needed. The probability of response to second line chemotherapy following platinum-based treatments is usually related to the platinum-free interval, even if recent studies have reported some other clinical features as having prognostic value, such as tumour burden and histology. Salvage monochemotherapy is generally used, but when the platinum-free interval is longer than 24 months, re-treatment with platinum compounds and/or taxanes is indicated. Moreover, a number of new agents with demonstrated activity in ovarian cancer are currently available. Sequentially used in recurrent disease, these agents may improve survival and/or quality of life. Among these new drugs, the most promising are: topotecan, doxil, gemcitabine and platinum analogues such as oxaliplatin, nedaplatin, satraplatin, BBR3464 and ZD0473. However, the real aim of salvage chemotherapy in relapsed ovarian cancer still remains palliative care, because complete responses are very rarely reported and long lasting responses are very seldom observed.

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Copy and paste a formatted citation
Spandidos Publications style
Latorre A, De Lena M, Catino A, Crucitta E, Sambiasi D, Guida M, Misino A and Lorusso V: Epithelial ovarian cancer: Second and third line chemotherapy (Review). Int J Oncol 21: 179-186, 2002.
APA
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M. ... Lorusso, V. (2002). Epithelial ovarian cancer: Second and third line chemotherapy (Review). International Journal of Oncology, 21, 179-186. https://doi.org/10.3892/ijo.21.1.179
MLA
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M., Misino, A., Lorusso, V."Epithelial ovarian cancer: Second and third line chemotherapy (Review)". International Journal of Oncology 21.1 (2002): 179-186.
Chicago
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M., Misino, A., Lorusso, V."Epithelial ovarian cancer: Second and third line chemotherapy (Review)". International Journal of Oncology 21, no. 1 (2002): 179-186. https://doi.org/10.3892/ijo.21.1.179
Copy and paste a formatted citation
x
Spandidos Publications style
Latorre A, De Lena M, Catino A, Crucitta E, Sambiasi D, Guida M, Misino A and Lorusso V: Epithelial ovarian cancer: Second and third line chemotherapy (Review). Int J Oncol 21: 179-186, 2002.
APA
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M. ... Lorusso, V. (2002). Epithelial ovarian cancer: Second and third line chemotherapy (Review). International Journal of Oncology, 21, 179-186. https://doi.org/10.3892/ijo.21.1.179
MLA
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M., Misino, A., Lorusso, V."Epithelial ovarian cancer: Second and third line chemotherapy (Review)". International Journal of Oncology 21.1 (2002): 179-186.
Chicago
Latorre, A., De Lena, M., Catino, A., Crucitta, E., Sambiasi, D., Guida, M., Misino, A., Lorusso, V."Epithelial ovarian cancer: Second and third line chemotherapy (Review)". International Journal of Oncology 21, no. 1 (2002): 179-186. https://doi.org/10.3892/ijo.21.1.179
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