Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines

  • Authors:
    • Mahmud T.H. Khan
    • Ilaria Lampronti
    • Dino Martello
    • Nicoletta Bianchi
    • Shaila Jabbar
    • M. S.K. Choudhuri
    • B. K. Datta
    • Roberto Gambari
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/ijo.21.1.187
  • Pages: 187-192
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Abstract

In this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, erythroleukemic HEL cell lines. Extracts from Emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from Terminalia arjuna, Aphanamixis polystachya, Oroxylum indicum, Cuscuta reflexa, Aegle marmelos, Saraca asoka, Rumex maritimus, Lagerstroemia speciosa, Red Sandalwood. Emblica officinalis extracts have been studied previously, due to their hepatoprotective, antioxidant, antifungal, antimicrobial and anti-inflammatory medicinal activities. Gas chromatography/mass spectrometry analyses allowed to identify pyrogallol as the common compound present both in unfractionated and n-butanol fraction of Emblica officinalis extracts. Antiproliferative effects of pyrogallol were therefore determined on human tumor cell lines thus identifying pyrogallol as an active component of Emblica officinalis extracts.

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July 2002
Volume 21 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Khan MT, Lampronti I, Martello D, Bianchi N, Jabbar S, Choudhuri MS, Datta BK and Gambari R: Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines. Int J Oncol 21: 187-192, 2002
APA
Khan, M.T., Lampronti, I., Martello, D., Bianchi, N., Jabbar, S., Choudhuri, M.S. ... Gambari, R. (2002). Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines. International Journal of Oncology, 21, 187-192. https://doi.org/10.3892/ijo.21.1.187
MLA
Khan, M. T., Lampronti, I., Martello, D., Bianchi, N., Jabbar, S., Choudhuri, M. S., Datta, B. K., Gambari, R."Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines". International Journal of Oncology 21.1 (2002): 187-192.
Chicago
Khan, M. T., Lampronti, I., Martello, D., Bianchi, N., Jabbar, S., Choudhuri, M. S., Datta, B. K., Gambari, R."Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines". International Journal of Oncology 21, no. 1 (2002): 187-192. https://doi.org/10.3892/ijo.21.1.187