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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2002 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 21 Issue 3

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Article

Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter

  • Authors:
    • Jing Liu
    • Wei-Guo Zou
    • Ming-Fei Lang
    • Jia Luo
    • Lan-Ying Sun
    • Xiao-Ning Wang
    • Qi-Jun Qian
    • Xin-Yuan Liu

  • View Affiliations / Copyright

    Affiliations: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China
  • Pages: 661-666
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijo.21.3.661
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Abstract

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of the telomerase, is transcriptionally upregulated in more than 90% of tumor cells. It may be used as a tool for driving a gene to kill tumors specifically. To test this idea, luciferase reporter gene was used and the results showed that hTERT promoter could restrict the gene expression in the telomerase-positive tumor cells. A tumor-specific expression plasmid phTERT-CD was constructed, in which the E. coli cytosine deaminase (CD) gene was controlled by the hTERT promoter. A colorectal cancer cell line (LoVo) and a normal amnion cell line (WISH) were transfected by this plasmid. It was shown that the expression of the CD gene increased the sensitivity of LoVo cells to the prodrug, 5-fluorocytosine (5FC), over 800-fold, while the sensitivity of WISH cells to 5FC was increased only 6-fold. Mixed cell experiments showed a strong on CD-negative cells. Furthermore, a significant anti-tumor effect of the phTERT-CD/5FC system was observed in nude mice bearing mammalian carcinoma induced by s.c. inoculation of LoVo cells when the mice were given 250 mg/kg 5FC twice a day for 10 consecutive days. These results indicated that hTERT promoter could target the suicidal effect of CD gene to tumor cells, and therefore, may be a novel and promising targeting approach to the treatment of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Zou W, Lang M, Luo J, Sun L, Wang X, Qian Q and Liu X: Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int J Oncol 21: 661-666, 2002.
APA
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X. ... Liu, X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. International Journal of Oncology, 21, 661-666. https://doi.org/10.3892/ijo.21.3.661
MLA
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X., Qian, Q., Liu, X."Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter". International Journal of Oncology 21.3 (2002): 661-666.
Chicago
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X., Qian, Q., Liu, X."Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter". International Journal of Oncology 21, no. 3 (2002): 661-666. https://doi.org/10.3892/ijo.21.3.661
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Zou W, Lang M, Luo J, Sun L, Wang X, Qian Q and Liu X: Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int J Oncol 21: 661-666, 2002.
APA
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X. ... Liu, X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. International Journal of Oncology, 21, 661-666. https://doi.org/10.3892/ijo.21.3.661
MLA
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X., Qian, Q., Liu, X."Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter". International Journal of Oncology 21.3 (2002): 661-666.
Chicago
Liu, J., Zou, W., Lang, M., Luo, J., Sun, L., Wang, X., Qian, Q., Liu, X."Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter". International Journal of Oncology 21, no. 3 (2002): 661-666. https://doi.org/10.3892/ijo.21.3.661
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