Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer

  • Authors:
    • S. J. Wigmore
    • K. C.H. Fearon
    • K. Sangster
    • J. P. Maingay
    • O. J. Garden
    • J. A. Ross
  • View Affiliations

  • Published online on: October 1, 2002     https://doi.org/10.3892/ijo.21.4.881
  • Pages: 881-886
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Abstract

Patients with pancreatic cancer frequently demonstrate symptoms such as weight-loss and muscle wasting and have clinical evidence of a systemic inflammatory response. Such effects may be mediated by pro-inflammatory cytokines derived from tumor cells. The production of interleukin-6 and -8 by pancreatic cancer cell lines and the influence of other cytokines on this production was studied. IL-8 was produced by all cell lines and production was increased following exposure to IL-1 and TNF. Cytokine-stimulated, but not basal IL-8 production was reduced by co-incubation with IL-4 in the MIA PaCa-2 and PANC-1 cell lines. The CFPAC cell line produced IL-6, but this production was not altered by IL-1, TNF or IL-4. In the PANC-1 cell line IL-8 and IL-8 receptors were only detected by PCR in cells which had been stimulated with TNF or IL-1. Serum concentrations of IL-6 and IL-8 were elevated in patients with pancreatic cancer compared with controls. In conclusion, human pancreatic cancer cell lines elaborate pro-inflammatory cytokines which have the potential to mediate elements of the systemic inflammatory response.

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October 2002
Volume 21 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Wigmore, S.J., Fearon, K.C., Sangster, K., Maingay, J.P., Garden, O.J., & Ross, J.A. (2002). Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. International Journal of Oncology, 21, 881-886. https://doi.org/10.3892/ijo.21.4.881
MLA
Wigmore, S. J., Fearon, K. C., Sangster, K., Maingay, J. P., Garden, O. J., Ross, J. A."Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer". International Journal of Oncology 21.4 (2002): 881-886.
Chicago
Wigmore, S. J., Fearon, K. C., Sangster, K., Maingay, J. P., Garden, O. J., Ross, J. A."Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer". International Journal of Oncology 21, no. 4 (2002): 881-886. https://doi.org/10.3892/ijo.21.4.881