O6-Methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma

  • Authors:
    • Anne Cayre
    • Frederique Penault-Llorca
    • Monique De Latour
    • Christine Rolhion
    • Viviane Feillel
    • Jean-Pierre Ferriere
    • Fabrice Kwiatkowski
    • Francoise Finat-Duclos
    • Pierre Verrelle
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/ijo.21.5.1125
  • Pages: 1125-1131
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

O6-Methylguanine-DNA methyl transferase (MGMT) in human carcinomas has been associated with tumor resistance to alkylating agents. The aims of this study were: i) to correlate tumor MGMT expression and patient and tumor characteristics in malignant breast carcinomas treated with induction chemotherapy including cyclophosphamide (CPM) and ii) to study the predictive and prognostic values of tumor MGMT gene expression. We used RT-PCR to measure the levels of tumor MGMT expression in 107 patients with breast carcinomas prior to neoadjuvant chemotherapy. Sixty patients (56%) received anthracyclines and CPM and 47 (44%) received only anthracyclines. Low levels of MGMT expression correlated with Scarff-Bloom-Richardson grade III (p<0.005), elevated S-phase (p<0.05), negative estrogen receptors (p<0.05), metastatic status (p<0.05) and occurrence of death (p=0.01). MGMT expression was not predictive of treatment response. Unexpectedly, survival was longer when tumor MGMT expression was high (p<0.005). The 4-year survival rate was 76% for high level MGMT patients and only 55% for others. This difference is also significant using the COX model (p<0.05). In breast cancer, tumor MGMT expression was not predictive of response to CPM. A low MGMT expression was significantly related to poor survival.

Related Articles

Journal Cover

November 2002
Volume 21 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cayre A, Penault-Llorca F, De Latour M, Rolhion C, Feillel V, Ferriere J, Kwiatkowski F, Finat-Duclos F and Verrelle P: O6-Methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma. Int J Oncol 21: 1125-1131, 2002.
APA
Cayre, A., Penault-Llorca, F., De Latour, M., Rolhion, C., Feillel, V., Ferriere, J. ... Verrelle, P. (2002). O6-Methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma. International Journal of Oncology, 21, 1125-1131. https://doi.org/10.3892/ijo.21.5.1125
MLA
Cayre, A., Penault-Llorca, F., De Latour, M., Rolhion, C., Feillel, V., Ferriere, J., Kwiatkowski, F., Finat-Duclos, F., Verrelle, P."O6-Methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma". International Journal of Oncology 21.5 (2002): 1125-1131.
Chicago
Cayre, A., Penault-Llorca, F., De Latour, M., Rolhion, C., Feillel, V., Ferriere, J., Kwiatkowski, F., Finat-Duclos, F., Verrelle, P."O6-Methylguanine-DNA methyl transferase gene expression and prognosis in breast carcinoma". International Journal of Oncology 21, no. 5 (2002): 1125-1131. https://doi.org/10.3892/ijo.21.5.1125