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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Article

Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells

  • Authors:
    • Radoslaw Zagozdzon
    • Cécile Bougeret
    • Yigong Fu
    • Hava Karsenty Avraham

  • View Affiliations / Copyright

    Affiliations: Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 1347-1352
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1347
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Abstract

The serine/threonine kinase Akt has recently been the focus of intense research. Akt activation requires the phosphorylation of both Thr-308 and Ser-473. Src kinase was shown to induce activation of Akt, while Lyn kinase seems to inhibit this activation. In the present study, we investigated the effect of overexpressing the Csk homologous kinase (CHK), an inhibitor of Src-family kinases, on the phosphorylation of Akt induced by two different factors: heregulin or cisplatin. We used MCF-7 cells stably overexpressing the wild-type CHK [CHK(wt)] or dead-kinase CHK [CHK(dk)]. We observed that in MCF-7 CHK(wt) cells Lyn kinase activity was more profoundly inhibited than Src kinase activity. When the cells were stimulated with heregulin or cisplatin, Akt phosphorylation occurred more rapidly in MCF-7 CHK(wt) cells in comparison to the other clones used. Interestingly, MCF-7 CHK(wt) cells in vitro were markedly more resistant to cisplatin than the other clones used in the experiments, and surprisingly chemical inhibition of Akt phosphorylation did not influence this resistance. In summary, our results show facilitation of Akt phosphorylation by the overexpression of CHK, and provide new insight into the putative role of CHK in human cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zagozdzon R, Bougeret C, Fu Y and Avraham HK: Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. Int J Oncol 21: 1347-1352, 2002.
APA
Zagozdzon, R., Bougeret, C., Fu, Y., & Avraham, H.K. (2002). Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. International Journal of Oncology, 21, 1347-1352. https://doi.org/10.3892/ijo.21.6.1347
MLA
Zagozdzon, R., Bougeret, C., Fu, Y., Avraham, H. K."Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells". International Journal of Oncology 21.6 (2002): 1347-1352.
Chicago
Zagozdzon, R., Bougeret, C., Fu, Y., Avraham, H. K."Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells". International Journal of Oncology 21, no. 6 (2002): 1347-1352. https://doi.org/10.3892/ijo.21.6.1347
Copy and paste a formatted citation
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Spandidos Publications style
Zagozdzon R, Bougeret C, Fu Y and Avraham HK: Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. Int J Oncol 21: 1347-1352, 2002.
APA
Zagozdzon, R., Bougeret, C., Fu, Y., & Avraham, H.K. (2002). Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells. International Journal of Oncology, 21, 1347-1352. https://doi.org/10.3892/ijo.21.6.1347
MLA
Zagozdzon, R., Bougeret, C., Fu, Y., Avraham, H. K."Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells". International Journal of Oncology 21.6 (2002): 1347-1352.
Chicago
Zagozdzon, R., Bougeret, C., Fu, Y., Avraham, H. K."Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells". International Journal of Oncology 21, no. 6 (2002): 1347-1352. https://doi.org/10.3892/ijo.21.6.1347
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