Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy

  • Authors:
    • Erika Bohl Kullberg
    • Jörgen Carlsson
    • Katarina Edwards
    • Jacek Capala
    • Stefan Sjöberg
    • Lars Gedda
  • View Affiliations

  • Published online on: August 1, 2003     https://doi.org/10.3892/ijo.23.2.461
  • Pages: 461-467
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Abstract

Liposomes are, when coupled to receptor ligands, candidates for receptor mediated delivery of boron for tumour therapy since they have capacity to deliver large amounts of boron per receptor interaction. With EGF-liposomes we present a pegylated ligand liposome delivery vehicle, containing water soluble boronated phenanthridine, WSP1, or water soluble boronated acridine, WSA1, for EGFR targeting. In the case of WSA1 a ligand dependent uptake was obtained and the boron uptake was as good as if free WSA1 was given. No ligand dependent boron uptake was seen for WSP1 containing liposomes. Thus, WSA1 is a candidate for further studies. Approximately 105 boron atoms were in each liposome. A critical assessment indicates that after optimization up to 106 boron atoms can be loaded. Since it is known that, for therapeutic effect, approximately 108-109 boron atoms are needed in a single tumour cell it is realized that 102-103 receptor interactions are needed to meet the demand. Tests applying cultured glioma cells indicate, without optimization of the delivery conditions, a boron uptake in the ppm range, which is necessary for successful BNCT. Thus, it seems possible to kill micro-invasive tumour cells with targeted liposomes if the delivery conditions are optimal.

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August 2003
Volume 23 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Bohl Kullberg E, Carlsson J, Edwards K, Capala J, Sjöberg S and Gedda L: Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. Int J Oncol 23: 461-467, 2003
APA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., & Gedda, L. (2003). Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy. International Journal of Oncology, 23, 461-467. https://doi.org/10.3892/ijo.23.2.461
MLA
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23.2 (2003): 461-467.
Chicago
Bohl Kullberg, E., Carlsson, J., Edwards, K., Capala, J., Sjöberg, S., Gedda, L."Introductory experiments on ligand liposomes as delivery agents for boron neutron capture therapy". International Journal of Oncology 23, no. 2 (2003): 461-467. https://doi.org/10.3892/ijo.23.2.461