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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2005 Volume 26 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 26 Issue 2

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Article

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern

  • Authors:
    • Mathewos Tessema
    • Florian Länger
    • Oliver Bock
    • Axel Seltsam
    • Kathleen Metzig
    • Britta Hasemeier
    • Hans Kreipe
    • Ulrich Lehmann

  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, Medizinische Hochschule Hannover, D-30625 Hannover, Germany
  • Pages: 499-507
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijo.26.2.499
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Abstract

H19 and IGF-2 are two growth regulatory genes located on chromosome 11p15 implicated in tumorigenesis. Both genes are imprinted and regulated reciprocally under many circumstances. In order to elucidate the contribution of H19 and IGF-2 to leukemogenesis, the mRNA expression level of both genes were quantitated in bone marrow biopsies and peripheral blood samples from normal (n=98), chronic myelomonocytic leukemia (CMML, n=43), chronic myelogenous leukemia (CML, n=40) and, acute myelogenous leukemia (AML, n=32) cases. A concomitant reduction of H19 and IGF-2 expression was observed in all leukemic samples compared to the healthy controls. This down-regulation was not accompanied by changes in methylation of the differentially methylated region (DMR). Whereas the H19 gene showed strict monoallelic expression in all informative normal (n=31) and leukemic (n=54) samples, the imprinting pattern of the IGF2 gene was found to be heterogeneous. No correlations between imprinting status (mono- versus biallelic expression), quantitative mRNA expression levels and course of disease were found for the IGF-2 gene. The data suggest a disturbed regulation of the IGF-2/H19 locus in myeloid leukemias which is not caused by loss of imprinting.

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Copy and paste a formatted citation
Spandidos Publications style
Tessema M, Länger F, Bock O, Seltsam A, Metzig K, Hasemeier B, Kreipe H and Lehmann U: Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. Int J Oncol 26: 499-507, 2005.
APA
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B. ... Lehmann, U. (2005). Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. International Journal of Oncology, 26, 499-507. https://doi.org/10.3892/ijo.26.2.499
MLA
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B., Kreipe, H., Lehmann, U."Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern". International Journal of Oncology 26.2 (2005): 499-507.
Chicago
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B., Kreipe, H., Lehmann, U."Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern". International Journal of Oncology 26, no. 2 (2005): 499-507. https://doi.org/10.3892/ijo.26.2.499
Copy and paste a formatted citation
x
Spandidos Publications style
Tessema M, Länger F, Bock O, Seltsam A, Metzig K, Hasemeier B, Kreipe H and Lehmann U: Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. Int J Oncol 26: 499-507, 2005.
APA
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B. ... Lehmann, U. (2005). Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. International Journal of Oncology, 26, 499-507. https://doi.org/10.3892/ijo.26.2.499
MLA
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B., Kreipe, H., Lehmann, U."Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern". International Journal of Oncology 26.2 (2005): 499-507.
Chicago
Tessema, M., Länger, F., Bock, O., Seltsam, A., Metzig, K., Hasemeier, B., Kreipe, H., Lehmann, U."Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern". International Journal of Oncology 26, no. 2 (2005): 499-507. https://doi.org/10.3892/ijo.26.2.499
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