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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2005 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2005 Volume 27 Issue 1

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Article

Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma

  • Authors:
    • Kentaro Yuge
    • Tomoyuki Takahashi
    • Satoshi Nagano
    • Yasuhiro Terazaki
    • Yoshiteru Murofushi
    • Hiroaki Ushikoshi
    • Takao Kawai
    • Ngin Cin Khai
    • Toshikazu Nakamura
    • Hisayoshi Fujiwara
    • Ken-Ichiro Kosai

  • View Affiliations / Copyright

    Affiliations: Department of Gene Therapy and Regenerative Medicine, Gifu University School of Medicine, Gifu, Japan
  • Pages: 77-85
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/ijo.27.1.77
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Abstract

Hepatocyte growth factor (HGF) gene therapy may have potential for treating chronic hepatitis (CH) and liver cirrhosis (LC). However, the lack of an HGF gene therapy study on hepatomas that are often associated with CH or LC, together with the stimulatory effects of HGF on many types of cancer, may hamper its application. This study explored the effects of adenoviral HGF gene transduction and their mechanisms on two types of hepatoma cells (hepatoblastoma and hepatocellular carcinoma) in in vitro experiments. Both types of hepatomas were revealed to have higher adenoviral gene transduction efficiencies and more efficient expressions of the HGF transgene, which successfully activated the HGF receptor/c-Met in an autocrine fashion, than those of other types of cancer. Notably, not only HGF, but also adenoviral infection, inhibited DNA synthesis, whereas only HGF but not adenoviral infection exerted a potent apoptotic effect. Moreover, adenoviral HGF gene transduction additively exerted inhibitory effects on cisplatin-treated hepatomas. In conclusion, inhibitory and apoptotic effects of adenoviral HGF gene transduction in hepatomas in contrast to potent mitogenic and antiapoptotic effects of HGF for hepatocytes are not only of biological interest, but also pose clinical benefits for adenoviral HGF gene therapy for CH and LC.

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Copy and paste a formatted citation
Spandidos Publications style
Yuge K, Takahashi T, Nagano S, Terazaki Y, Murofushi Y, Ushikoshi H, Kawai T, Khai NC, Nakamura T, Fujiwara H, Fujiwara H, et al: Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. Int J Oncol 27: 77-85, 2005.
APA
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H. ... Kosai, K. (2005). Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. International Journal of Oncology, 27, 77-85. https://doi.org/10.3892/ijo.27.1.77
MLA
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H., Kawai, T., Khai, N. C., Nakamura, T., Fujiwara, H., Kosai, K."Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma". International Journal of Oncology 27.1 (2005): 77-85.
Chicago
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H., Kawai, T., Khai, N. C., Nakamura, T., Fujiwara, H., Kosai, K."Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma". International Journal of Oncology 27, no. 1 (2005): 77-85. https://doi.org/10.3892/ijo.27.1.77
Copy and paste a formatted citation
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Spandidos Publications style
Yuge K, Takahashi T, Nagano S, Terazaki Y, Murofushi Y, Ushikoshi H, Kawai T, Khai NC, Nakamura T, Fujiwara H, Fujiwara H, et al: Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. Int J Oncol 27: 77-85, 2005.
APA
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H. ... Kosai, K. (2005). Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. International Journal of Oncology, 27, 77-85. https://doi.org/10.3892/ijo.27.1.77
MLA
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H., Kawai, T., Khai, N. C., Nakamura, T., Fujiwara, H., Kosai, K."Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma". International Journal of Oncology 27.1 (2005): 77-85.
Chicago
Yuge, K., Takahashi, T., Nagano, S., Terazaki, Y., Murofushi, Y., Ushikoshi, H., Kawai, T., Khai, N. C., Nakamura, T., Fujiwara, H., Kosai, K."Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma". International Journal of Oncology 27, no. 1 (2005): 77-85. https://doi.org/10.3892/ijo.27.1.77
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