A dog pedigree with familial medullary thyroid cancer

  • Authors:
    • Jia-Jing Lee
    • Catharina Larsson
    • Weng-Onn Lui
    • Anders Höög
    • Henrik Von Euler
  • View Affiliations

  • Published online on: November 1, 2006     https://doi.org/10.3892/ijo.29.5.1173
  • Pages: 1173-1182
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Abstract

Multiple endocrine neoplasia (MEN) is defined as concurrent neoplasia or hyperplasia in more than one endocrine gland. MEN is well known in humans and has also been reported in small animals. We report on a dog family of a mixed breed with Alaskan malamute as a major influence, where three members developed thyroid carcinomas and another dog had clinical signs mimicking the other three but without a confirmed diagnosis. The age of onset of the tumour was between 96-109 months. Clinical, biochemical and immunohistochemical examinations revealed that the affected individuals typically demonstrated symptoms including calcitonin positive thyroid cancer, hypothyroidism and chronic dermatitis. In addition, elevated serum calcium and multinodular adrenocortical hyperplasia were demonstrated in a single member. The diagnosis observed is similar to the familial form of medullary thyroid carcinoma (FMTC) in human. This is the first report of FMTC in dog. Up to 95% of FMTC and MEN2 is known to be caused by activating mutations in the RET gene. The dog Ret gene was analysed as a candidate in this pedigree. The complete dog Ret genomic sequence was predicted in silico. The lack of demonstratable Ret mutation suggests the involvement of alternative predisposing mutation in this pedigree. The unique occurrence of familial MTC makes this potentially an important model in further defining the genetic basis of MTC.

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November 2006
Volume 29 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee J, Larsson C, Lui W, Höög A and Von Euler H: A dog pedigree with familial medullary thyroid cancer. Int J Oncol 29: 1173-1182, 2006.
APA
Lee, J., Larsson, C., Lui, W., Höög, A., & Von Euler, H. (2006). A dog pedigree with familial medullary thyroid cancer. International Journal of Oncology, 29, 1173-1182. https://doi.org/10.3892/ijo.29.5.1173
MLA
Lee, J., Larsson, C., Lui, W., Höög, A., Von Euler, H."A dog pedigree with familial medullary thyroid cancer". International Journal of Oncology 29.5 (2006): 1173-1182.
Chicago
Lee, J., Larsson, C., Lui, W., Höög, A., Von Euler, H."A dog pedigree with familial medullary thyroid cancer". International Journal of Oncology 29, no. 5 (2006): 1173-1182. https://doi.org/10.3892/ijo.29.5.1173