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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1993 Volume 3 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1993 Volume 3 Issue 1

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Article

INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION

  • Authors:
    • R RAMANATHAN
    • NP DAS
    • CH TAN

  • View Affiliations / Copyright

    Affiliations: NATL UNIV SINGAPORE,FAC MED,DEPT BIOCHEM,FLAVONOID RES LAB,SINGAPORE 0511,SINGAPORE.
  • Pages: 115-119
    |
    Published online on: July 1, 1993
       https://doi.org/10.3892/ijo.3.1.115
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Abstract

The effect of thirty-one flavonoids on monolayer HeLa cell proliferation was studied and their structure activity relationship was rationalised. The flavones, flavonols and chalcones possessing the C2,3-double bond were the most potent cytotoxic groups of compounds. The IC50 values for 2-hydroxy chalcone (the most potent flavonoid) and the cytotoxic drug colchicine, were 8 muM and < 0.1 muM, respectively. Whilst colchicine was able to inhibit the incorporation of [C-14] thymidine, uridine and leucine into HeLa cells, 2-hydroxy chalcone inhibited the incorporation of the two nucleotides, but not the amino acid. This indicates that the mode of action of 2-hydroxy chalcone and colchicine are different.

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Copy and paste a formatted citation
Spandidos Publications style
RAMANATHAN R, DAS N and TAN C: INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. Int J Oncol 3: 115-119, 1993.
APA
RAMANATHAN, R., DAS, N., & TAN, C. (1993). INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. International Journal of Oncology, 3, 115-119. https://doi.org/10.3892/ijo.3.1.115
MLA
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3.1 (1993): 115-119.
Chicago
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3, no. 1 (1993): 115-119. https://doi.org/10.3892/ijo.3.1.115
Copy and paste a formatted citation
x
Spandidos Publications style
RAMANATHAN R, DAS N and TAN C: INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. Int J Oncol 3: 115-119, 1993.
APA
RAMANATHAN, R., DAS, N., & TAN, C. (1993). INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. International Journal of Oncology, 3, 115-119. https://doi.org/10.3892/ijo.3.1.115
MLA
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3.1 (1993): 115-119.
Chicago
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3, no. 1 (1993): 115-119. https://doi.org/10.3892/ijo.3.1.115
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