INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION

  • Authors:
    • R RAMANATHAN
    • NP DAS
    • CH TAN
  • View Affiliations

  • Published online on: July 1, 1993     https://doi.org/10.3892/ijo.3.1.115
  • Pages: 115-119
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Abstract

The effect of thirty-one flavonoids on monolayer HeLa cell proliferation was studied and their structure activity relationship was rationalised. The flavones, flavonols and chalcones possessing the C2,3-double bond were the most potent cytotoxic groups of compounds. The IC50 values for 2-hydroxy chalcone (the most potent flavonoid) and the cytotoxic drug colchicine, were 8 muM and < 0.1 muM, respectively. Whilst colchicine was able to inhibit the incorporation of [C-14] thymidine, uridine and leucine into HeLa cells, 2-hydroxy chalcone inhibited the incorporation of the two nucleotides, but not the amino acid. This indicates that the mode of action of 2-hydroxy chalcone and colchicine are different.

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July 1993
Volume 3 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RAMANATHAN R, DAS N and TAN C: INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. Int J Oncol 3: 115-119, 1993
APA
RAMANATHAN, R., DAS, N., & TAN, C. (1993). INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION. International Journal of Oncology, 3, 115-119. https://doi.org/10.3892/ijo.3.1.115
MLA
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3.1 (1993): 115-119.
Chicago
RAMANATHAN, R., DAS, N., TAN, C."INHIBITORY EFFECTS OF 2-HYDROXY CHALCONE AND OTHER FLAVONOIDS ON HUMAN CANCER CELL-PROLIFERATION". International Journal of Oncology 3, no. 1 (1993): 115-119. https://doi.org/10.3892/ijo.3.1.115