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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1993 Volume 3 Issue 2

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Article

AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS

  • Authors:
    • K MAYER
    • WG BALLHAUSEN

  • View Affiliations / Copyright

    Affiliations: UNIV ERLANGEN NURNBERG,INST HUMANGENET,SCHWABACHANLAGE 10,W-8520 ERLANGEN,GERMANY.
  • Pages: 369-373
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.369
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Abstract

Detection of lck-specific transcripts has been discussed as a marker for metastasis of epithelial tumor cells. Since it is known that lck expression is regulated post-transcriptionally, it was fundamental to us to identify lck in human colorectal cancer cell lines also at the protein level. Subsequently, RT-PCR was used to confirm that lck-producing colorectal cancer cell lines contain mature transcripts initiated exclusively from the 3' promoter element. When transcriptional activity of the two different lck promoter elements was characterized in the colon cancer cell lines, we found the 3' promoter preferentially activated. Based on the results obtained from truncating this promoter element at its 5' end, we were able to define the major transcriptional activity of the downstream promoter to be regulated within a small region of only 90 bp upstream from the start site for lck type I transcripts. This finding will contribute to the identification of lymphocyte-specific transcription factors involved in the activation of the lck gene in metastatic colorectal carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
MAYER K and BALLHAUSEN W: AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS. Int J Oncol 3: 369-373, 1993.
APA
MAYER, K., & BALLHAUSEN, W. (1993). AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS. International Journal of Oncology, 3, 369-373. https://doi.org/10.3892/ijo.3.2.369
MLA
MAYER, K., BALLHAUSEN, W."AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS". International Journal of Oncology 3.2 (1993): 369-373.
Chicago
MAYER, K., BALLHAUSEN, W."AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS". International Journal of Oncology 3, no. 2 (1993): 369-373. https://doi.org/10.3892/ijo.3.2.369
Copy and paste a formatted citation
x
Spandidos Publications style
MAYER K and BALLHAUSEN W: AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS. Int J Oncol 3: 369-373, 1993.
APA
MAYER, K., & BALLHAUSEN, W. (1993). AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS. International Journal of Oncology, 3, 369-373. https://doi.org/10.3892/ijo.3.2.369
MLA
MAYER, K., BALLHAUSEN, W."AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS". International Journal of Oncology 3.2 (1993): 369-373.
Chicago
MAYER, K., BALLHAUSEN, W."AN ESSENTIAL CIS-ACTING ELEMENT OF THE LCK-3' PROMOTER REGULATES THE EXPRESSION OF P56(LCK) IN METASTATIC COLORECTAL-CANCER CELLS". International Journal of Oncology 3, no. 2 (1993): 369-373. https://doi.org/10.3892/ijo.3.2.369
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