POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES

  • Authors:
    • D YASUDA
    • H IGUCHI
    • Y IKEDA
    • S NISHIMURA
    • PS STEEG
    • T MISAWA
    • H NAWATA
    • A KONO
  • View Affiliations

  • Published online on: October 1, 1993     https://doi.org/10.3892/ijo.3.4.641
  • Pages: 641-644
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Abstract

Nm23 gene expression and Ki-ras point mutations of eight human pancreatic cancer-derived cell lines with different metastatic capabilities were studied. Nm23 gene expression was significantly reduced in the cell lines with a high metastatic potential as compared with those with a low meta static potential (p<0.05). The same mutation at codon 12 of the Ki-ras gene (Gly12 to Asp12) was found in all cell lines with a high metastatic potential. These findings suggest a possible association of metastatic potential with Nm23 gene expression as well as the mutation of Ki-ras gene in human pancreatic cancer.

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October 1993
Volume 3 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
YASUDA D, IGUCHI H, IKEDA Y, NISHIMURA S, STEEG P, MISAWA T, NAWATA H and KONO A: POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES. Int J Oncol 3: 641-644, 1993.
APA
YASUDA, D., IGUCHI, H., IKEDA, Y., NISHIMURA, S., STEEG, P., MISAWA, T. ... KONO, A. (1993). POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES. International Journal of Oncology, 3, 641-644. https://doi.org/10.3892/ijo.3.4.641
MLA
YASUDA, D., IGUCHI, H., IKEDA, Y., NISHIMURA, S., STEEG, P., MISAWA, T., NAWATA, H., KONO, A."POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES". International Journal of Oncology 3.4 (1993): 641-644.
Chicago
YASUDA, D., IGUCHI, H., IKEDA, Y., NISHIMURA, S., STEEG, P., MISAWA, T., NAWATA, H., KONO, A."POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES". International Journal of Oncology 3, no. 4 (1993): 641-644. https://doi.org/10.3892/ijo.3.4.641