AVM (ADRIAMYCIN, VINBLASTINE, METHOTREXATE) NEOADJUVANT CHEMOTHERAPY IN ADVANCED OR INFLAMMATORY CARCINOMA OF THE BREAST

  • Authors:
    • P ZOLA
    • G SCHNAPPER
    • D KATSAROS
    • F GENTA
    • MG BAU
    • AM FERRERO
    • L GALLETTO
    • P SISMONDI
  • View Affiliations

  • Published online on: November 1, 1993     https://doi.org/10.3892/ijo.3.5.869
  • Pages: 869-872
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Abstract

Thirty-eight consecutive patients with locally advanced (stage IIIb/IVa-c) or inflammatory breast cancer (stage IVd) underwent neoadjuvant chemotherapy in our department between 1978-1990. All patients in this phase II study, received from three to five courses of neoadjuvant AVM regimen (Adriamycin, Vincristine, Methotrexate). Complete or partial response (CR+PR) was observed in 94.6% of this group of patients after the completion of therapy (chemotherapy + surgery + consolidation therapy) and in 97.3% at the completion of neoadjuvant chemotherapy alone. The overall 5-year median survival was 31.86% with a median disease-free time of 13 months. Only one patient showed progression of disease before surgery and was excluded from the study. The annual incidence of relapse in this study was 35% and the first metastatic event was observed locally in 1/4 of the patients examined. Low to moderate toxicity observed was reversible and easily controlled. We conclude that AVM neoadjuvant chemotherapy is a well tollerated regimen with long term clinical response in locally advanced breast cancer patients.

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November 1993
Volume 3 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ZOLA P, SCHNAPPER G, KATSAROS D, GENTA F, BAU M, FERRERO A, GALLETTO L and SISMONDI P: AVM (ADRIAMYCIN, VINBLASTINE, METHOTREXATE) NEOADJUVANT CHEMOTHERAPY IN ADVANCED OR INFLAMMATORY CARCINOMA OF THE BREAST. Int J Oncol 3: 869-872, 1993
APA
ZOLA, P., SCHNAPPER, G., KATSAROS, D., GENTA, F., BAU, M., FERRERO, A. ... SISMONDI, P. (1993). AVM (ADRIAMYCIN, VINBLASTINE, METHOTREXATE) NEOADJUVANT CHEMOTHERAPY IN ADVANCED OR INFLAMMATORY CARCINOMA OF THE BREAST. International Journal of Oncology, 3, 869-872. https://doi.org/10.3892/ijo.3.5.869
MLA
ZOLA, P., SCHNAPPER, G., KATSAROS, D., GENTA, F., BAU, M., FERRERO, A., GALLETTO, L., SISMONDI, P."AVM (ADRIAMYCIN, VINBLASTINE, METHOTREXATE) NEOADJUVANT CHEMOTHERAPY IN ADVANCED OR INFLAMMATORY CARCINOMA OF THE BREAST". International Journal of Oncology 3.5 (1993): 869-872.
Chicago
ZOLA, P., SCHNAPPER, G., KATSAROS, D., GENTA, F., BAU, M., FERRERO, A., GALLETTO, L., SISMONDI, P."AVM (ADRIAMYCIN, VINBLASTINE, METHOTREXATE) NEOADJUVANT CHEMOTHERAPY IN ADVANCED OR INFLAMMATORY CARCINOMA OF THE BREAST". International Journal of Oncology 3, no. 5 (1993): 869-872. https://doi.org/10.3892/ijo.3.5.869